{"id":"W1544552427","doi":"10.1038/79612","title":"Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility.","year":2000,"lang":"en","type":"article","venue":"Nature Structural Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health; Medical Research Council Canada; National Foundation for Cancer Research","keywords":"Aminoacylation; Transfer RNA; Biology; Mutant; Genetics; Heteroplasmy; Mutation; Point mutation; Mitochondrion; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126461,0.0009577423,0.0002526148,0.0005846672,0.0005273215,0.000273031,0.0003553023,0.001143964,0.002684716],"category_scores_gemma":[0.0009847925,0.000141996,0.000305526,0.0003247998,0.0007200121,0.0002222538,0.0004382473,0.000644923,0.0006677964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413016,"about_ca_system_score_gemma":0.0002571287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005083273,"about_ca_topic_score_gemma":0.0003521639,"domain_scores_codex":[0.9998205,0.00005945495,0.00002718466,0.00002949061,0.00003765602,0.00002571809],"domain_scores_gemma":[0.9993293,0.00016124,0.000222231,0.00005904995,0.00006565903,0.0001625546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001225961,0.0001577493,0.004792396,0.0001987512,0.0001104742,0.02261164,0.0001723722,0.00124211,0.9526979,0.003091926,0.001789807,0.01190879],"study_design_scores_gemma":[0.0002991844,0.001912597,0.06957959,0.0001283481,0.0003292125,0.185129,0.0004874673,0.005605482,0.7124794,0.007299135,0.01660401,0.0001465165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894326,0.001769054,0.003760422,0.0006644607,0.0002370281,0.00003373042,0.0008640849,0.0002327053,0.003005903],"genre_scores_gemma":[0.9980977,0.0003272554,0.0006079198,0.00008208365,0.00003175771,0.000007914022,0.0003582231,0.00002799419,0.00045917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002684716,"threshold_uncertainty_score":0.008981287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006132117016219588,"score_gpt":0.266044315219729,"score_spread":0.2599121982035095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}