{"id":"W1544638309","doi":"10.4049/jimmunol.1400854","title":"CD8+ TCR Bias and Immunodominance in HIV-1 Infection","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Lundbeckfonden; Wellcome Trust","keywords":"Immunodominance; Epitope; Biology; Immunology; Virology; CD8; Cytotoxic T cell; Immune system; Major histocompatibility complex; Antigen; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705498,0.0001207028,0.0001712141,0.0003373652,0.000152438,0.0003421796,0.0001008313,0.0001752045,0.0005286204],"category_scores_gemma":[0.0003469783,0.0001289251,0.00006243345,0.0002078766,0.0002874498,0.0002096437,0.0002770472,0.00021785,0.00008630751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001237497,"about_ca_system_score_gemma":0.0000878725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002283525,"about_ca_topic_score_gemma":0.0003366723,"domain_scores_codex":[0.9998079,0.00006676613,0.0000120522,0.00003782936,0.00002673633,0.00004879919],"domain_scores_gemma":[0.9998392,0.00004147845,0.00005308545,0.00001881837,0.00001249476,0.00003494842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008359824,0.0001024364,0.1185333,0.00008607403,0.00002729901,0.0002588487,0.0003066162,0.0005413765,0.8620614,0.0005754062,0.00004208104,0.01662909],"study_design_scores_gemma":[0.00003591861,0.001161525,0.904504,0.00003612386,0.00005468438,0.003148366,0.000482379,0.003561385,0.08384915,0.001925432,0.001217002,0.00002405093],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988937,0.0005287574,0.0002684385,0.000004895909,6.219275e-7,0.000003295989,0.00001163012,0.000003141628,0.0002855459],"genre_scores_gemma":[0.999598,0.000142755,0.0001495855,0.000007565488,0.000002189972,0.000002821438,0.00001143939,0.000001229373,0.00008454899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005286204,"threshold_uncertainty_score":0.00176847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03487741863154493,"score_gpt":0.278329941148323,"score_spread":0.2434525225167781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}