{"id":"W1544892070","doi":"10.4049/jimmunol.175.3.1785","title":"Mannose-Binding Lectin Recognizes Peptidoglycan via the <i>N</i> -Acetyl Glucosamine Moiety, and Inhibits Ligand-Induced Proinflammatory Effect and Promotes Chemokine Production by Macrophages","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Proinflammatory cytokine; Lectin; Peptidoglycan; Chemistry; Mannan-binding lectin; Glucosamine; Mannose; Ligand (biochemistry); Moiety; Biochemistry; Chemokine; Cell biology; Microbiology; Biology; Stereochemistry; Receptor; Immunology; Inflammation; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008468328,0.0003221701,0.000217053,0.0001085156,0.00008848456,0.0001265526,0.0001381217,0.0001593021,0.0009641856],"category_scores_gemma":[0.00006883911,0.00007002853,0.0001977614,0.00008509888,0.0001647546,0.00008465323,0.0001225364,0.0003579042,0.0002715647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160779,"about_ca_system_score_gemma":0.0002053332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005971558,"about_ca_topic_score_gemma":0.0009397679,"domain_scores_codex":[0.9998938,0.00002456756,0.000006982496,0.000008829084,0.00002904713,0.00003665355],"domain_scores_gemma":[0.9999672,0.000003304264,0.00000630846,0.000002751469,0.000004379584,0.00001596349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002358358,0.00009944956,0.0001801017,0.00004569131,0.000006677552,0.00002235453,0.00000506609,0.00003174279,0.9968773,0.00002256941,0.00008619226,0.002387019],"study_design_scores_gemma":[0.00008556104,0.002156308,0.008635404,0.00001374449,0.00001917038,0.0002698365,0.00001578819,0.0009190182,0.9846816,0.00003844274,0.003159404,0.000005707288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919379,0.00368398,0.001618892,0.000130077,0.00003596043,0.00003389439,0.0001175057,0.00009972227,0.002342006],"genre_scores_gemma":[0.9936283,0.001238311,0.001684497,0.0001126693,0.0000290543,0.00004985167,0.0003650868,0.000009627813,0.002882767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009641856,"threshold_uncertainty_score":0.003225565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006181877315187057,"score_gpt":0.2382151283141946,"score_spread":0.2320332509990076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}