{"id":"W1545075277","doi":"10.1002/jms.3412","title":"Mass spectrometric study of gas‐phase ions of acid β‐glucosidase (Cerezyme) and iminosugar pharmacological chaperones","year":2014,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Weizmann Institute of Science; H2020 European Research Council; Eli Lilly and Company","keywords":"Chemistry; Ion; Non-covalent interactions; Molecule; Covalent bond; Mass spectrometry; Chaperone (clinical); Enzyme; Gas phase; Glycoprotein; Calnexin; Crystallography; Stereochemistry; Biophysics; Biochemistry; Chromatography; Physical chemistry; Organic chemistry; Hydrogen bond","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835566,0.0005496544,0.0003727091,0.0003131047,0.0002060351,0.0003303101,0.000315581,0.000508789,0.0008847669],"category_scores_gemma":[0.0005243239,0.0001482676,0.0002930765,0.0003019848,0.0002343516,0.000245372,0.0002056641,0.0005186007,0.0002688243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061747,"about_ca_system_score_gemma":0.0002030855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000572366,"about_ca_topic_score_gemma":0.0002801437,"domain_scores_codex":[0.9997804,0.00003639176,0.000009409147,0.00005297153,0.0000746769,0.00004610703],"domain_scores_gemma":[0.9996179,0.0001037988,0.00009776897,0.00001838248,0.00008536137,0.00007678491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737829,0.00001361733,0.0002673242,0.00001971255,0.000008412943,0.00004213783,0.00002643626,0.00004138197,0.9983491,0.00005049095,0.00002975482,0.0009778657],"study_design_scores_gemma":[0.00001202326,0.0001684805,0.003638184,0.000005697281,0.00001322143,0.0002699024,0.00003231136,0.001131197,0.9937274,0.00004047314,0.0009547909,0.000006168695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875968,0.002332395,0.008203596,0.0001383791,0.00004259262,0.00002642561,0.000367196,0.0001729549,0.001119647],"genre_scores_gemma":[0.9854593,0.001123604,0.01014425,0.0002029205,0.00002940852,0.0000618953,0.0007697321,0.00007974435,0.002129182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008847669,"threshold_uncertainty_score":0.002959847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796557570208496,"score_gpt":0.3132393672876023,"score_spread":0.2952737915855174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}