{"id":"W1545075277","doi":"10.1002/jms.3412","title":"Mass spectrometric study of gas‐phase ions of acid β‐glucosidase (Cerezyme) and iminosugar pharmacological chaperones","year":2014,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Weizmann Institute of Science; H2020 European Research Council; Eli Lilly and Company","keywords":"Chemistry; Ion; Non-covalent interactions; Molecule; Covalent bond; Mass spectrometry; Chaperone (clinical); Enzyme; Gas phase; Glycoprotein; Calnexin; Crystallography; Stereochemistry; Biophysics; Biochemistry; Chromatography; Physical chemistry; Organic chemistry; Hydrogen bond","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008438308,0.0001787184,0.0004629413,0.0007776798,0.00006013207,0.00002036674,0.0003117096,0.0001216855,0.0003478616],"category_scores_gemma":[0.0004959198,0.0001427524,0.0001522678,0.0006743877,0.0001185093,0.00001346906,0.0001005784,0.0002993357,0.000002469847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889514,"about_ca_system_score_gemma":0.00006109499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006156817,"about_ca_topic_score_gemma":0.000002877827,"domain_scores_codex":[0.9980637,0.0002279848,0.0006580483,0.0002382746,0.0005305946,0.0002813925],"domain_scores_gemma":[0.9986486,0.00006177505,0.0005265369,0.0002432181,0.0003151124,0.0002047576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007939857,0.001360818,0.006051969,0.00003673149,0.0002169908,0.00002231501,0.00004492999,0.00001268339,0.9892607,0.00009588563,0.0001741613,0.001928834],"study_design_scores_gemma":[0.006374313,0.01585576,0.01508058,0.00001739147,0.0001179961,0.0001108655,0.00047361,0.0001363762,0.9608583,0.0002773598,0.0005255807,0.0001718941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942866,0.001099415,0.00343371,0.0001477045,0.00009776819,0.0002501225,0.00001187294,0.00000383624,0.0006689978],"genre_scores_gemma":[0.996412,0.0004102975,0.002812019,0.00002998109,0.0002442531,0.000003706427,0.000003911443,0.00001746681,0.0000664023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02840242,"threshold_uncertainty_score":0.5821273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796557570208496,"score_gpt":0.3132393672876023,"score_spread":0.2952737915855174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}