{"id":"W1545256187","doi":"10.4049/jimmunol.172.7.4266","title":"Enrichment of Lck in Lipid Rafts Regulates Colocalized Fyn Activation and the Initiation of Proximal Signals through TCRαβ","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute; Women's College Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"FYN; Lipid raft; T-cell receptor; Cell biology; Chemistry; Cancer research; Signal transduction; Biology; Proto-oncogene tyrosine-protein kinase Src; T cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007082489,0.0002180713,0.0001051549,0.0001418631,0.0001583539,0.0002529662,0.0001162028,0.0001320747,0.0007516905],"category_scores_gemma":[0.0000799871,0.00009238236,0.0001165523,0.00008609641,0.0001711658,0.00016012,0.0002462594,0.0003087764,0.0002978812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005223483,"about_ca_system_score_gemma":0.0001592766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000622007,"about_ca_topic_score_gemma":0.0009587191,"domain_scores_codex":[0.9999207,0.000007397888,0.000005046375,0.00001828808,0.0000168399,0.00003177872],"domain_scores_gemma":[0.9999373,0.000007939352,0.00002361134,0.000005314945,0.000006572777,0.0000193265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005391642,0.000006510702,0.0002080824,0.000005824768,9.056268e-7,0.00002736975,0.00000710127,0.0000274713,0.999369,0.00004413278,0.000006052429,0.0002435769],"study_design_scores_gemma":[0.000007813881,0.00004295836,0.007460094,0.000002457417,0.000004356597,0.0001880088,0.00002365558,0.0008348644,0.9908407,0.00005153509,0.0005412187,0.000002249292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987447,0.0001829376,0.0006348994,0.00001240007,0.000002286679,0.000005376184,0.00006696313,0.00001612136,0.0003343396],"genre_scores_gemma":[0.9983632,0.0001755215,0.0006593408,0.000008956076,0.000002737679,0.0000122465,0.0001608757,0.00001029469,0.0006068174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007516905,"threshold_uncertainty_score":0.003789902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008018592670649949,"score_gpt":0.2370868088297749,"score_spread":0.2290682161591249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}