{"id":"W1546223511","doi":"10.18433/j39014","title":"The Success Rate of New Drug Development in Clinical Trials: Crohn’s Disease","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Government of Canada","keywords":"Crohn's disease; Medicine; Drug; Disease; Clinical trial; Drug development; Drug trial; Internal medicine; Intensive care medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1110598,0.0004926331,0.001356985,0.00801299,0.0008041319,0.003588581,0.001086464,0.001726513,0.002884839],"category_scores_gemma":[0.320756,0.0003558385,0.001753251,0.006181845,0.002182655,0.003219407,0.001664431,0.001641538,0.001028632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001538045,"about_ca_system_score_gemma":0.001421851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005789718,"about_ca_topic_score_gemma":0.0008420444,"domain_scores_codex":[0.8763314,0.05109465,0.03109495,0.006270417,0.03388694,0.001321577],"domain_scores_gemma":[0.3202867,0.3737273,0.2485071,0.02032027,0.03311783,0.004040889],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001894836,0.00008915809,0.878777,0.003451217,0.00111852,0.0007084856,0.0009556041,0.0006556931,0.001135406,0.0009046583,0.002611103,0.1076983],"study_design_scores_gemma":[0.0001679011,0.003108298,0.9471318,0.003169545,0.002033557,0.0124792,0.001131429,0.002392774,0.0067755,0.001377629,0.02008788,0.0001445081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7952375,0.1542328,0.01166488,0.006848361,0.0003314529,0.001310997,0.004724681,0.0002424949,0.02540686],"genre_scores_gemma":[0.9867214,0.007971106,0.002888659,0.0005340565,0.0002760327,0.0001999312,0.0007125006,0.00004890283,0.0006474236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8889402,"threshold_uncertainty_score":0.5873471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2474602037292657,"score_gpt":0.5358302856649946,"score_spread":0.2883700819357289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}