{"id":"W1546380214","doi":"10.1002/9780470513750.ch6","title":"Loss of Genetic Information in Cancer","year":2007,"lang":"en","type":"article","venue":"Novartis Foundation symposium","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Regional Health Centre; Royal Victoria Hospital","funders":"","keywords":"Retinoblastoma; Hepatoblastoma; Biology; Locus (genetics); Genetics; Loss of heterozygosity; Allele; Cancer; Wilms' tumor; Chromosome; Genotype; Cancer research; Sarcoma; Rhabdomyosarcoma; Cytogenetics; Pathology; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003031942,0.0001201129,0.0001862053,0.0009370811,0.0005255783,0.001030887,0.0003399976,0.0005565648,0.002757129],"category_scores_gemma":[0.0008932307,0.00009084865,0.0001438581,0.001002699,0.0009522598,0.0004589499,0.0008467695,0.0006449691,0.0006828123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009721432,"about_ca_system_score_gemma":0.0005780956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208487,"about_ca_topic_score_gemma":0.0009189218,"domain_scores_codex":[0.9997299,0.00005457204,0.00002075381,0.00005519984,0.0001034551,0.0000360704],"domain_scores_gemma":[0.9996169,0.0001023472,0.00007037247,0.00005919393,0.00005141288,0.00009981659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008671213,0.000196803,0.07116923,0.0009002376,0.0001893411,0.01216848,0.0009839738,0.002060987,0.233935,0.1149571,0.0300801,0.5324917],"study_design_scores_gemma":[0.00007358198,0.0005465173,0.1154721,0.0004384748,0.000210766,0.05808999,0.0007697796,0.002101269,0.09263576,0.08091523,0.6486719,0.00007473752],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6278361,0.1738219,0.02108461,0.02703479,0.00133452,0.0001142166,0.003856847,0.0007386532,0.1441784],"genre_scores_gemma":[0.9637934,0.01986267,0.00256073,0.001557477,0.0001731745,0.00003292355,0.001292129,0.0000257851,0.01070187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757129,"threshold_uncertainty_score":0.009223521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00898402282371173,"score_gpt":0.270055458231984,"score_spread":0.2610714354082723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}