{"id":"W1546447454","doi":"","title":"Abstract 18482: Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate in Adolescents: An Open-label Phase IIa Study","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital; Boehringer Ingelheim (Canada); Children's Hospital of Eastern Ontario","funders":"","keywords":"Medicine; Dabigatran; Pharmacokinetics; Pharmacodynamics; Partial thromboplastin time; Pharmacology; Thrombin time; Prothrombin time; Direct thrombin inhibitor; Anesthesia; Warfarin; Internal medicine; Atrial fibrillation; Coagulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057386,0.0006987499,0.001215251,0.0001828459,0.0002542475,0.000670554,0.0002731338,0.0006764093,0.002953736],"category_scores_gemma":[0.0008602684,0.0003129361,0.0008767917,0.0001843455,0.0005078062,0.0006040302,0.0001919775,0.001995101,0.0008513932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000364589,"about_ca_system_score_gemma":0.0008403374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264177,"about_ca_topic_score_gemma":0.0005626528,"domain_scores_codex":[0.9995781,0.0002261245,0.00003647999,0.00005296207,0.00005502438,0.00005135449],"domain_scores_gemma":[0.9993559,0.0001361548,0.0001647315,0.00006779064,0.00005507194,0.0002203985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5981662,0.1121164,0.0331771,0.00138305,0.002595861,0.000757824,0.0006910198,0.002646405,0.09337188,0.0005565149,0.003622032,0.1509157],"study_design_scores_gemma":[0.2249968,0.7078534,0.04438847,0.0001048841,0.0009600404,0.000875831,0.0001251526,0.002057659,0.01092999,0.0002169401,0.007453038,0.00003789704],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957418,0.001356688,0.000731144,0.0001582008,0.00004295422,0.000747906,0.0004540116,0.00004716658,0.0007202172],"genre_scores_gemma":[0.9928779,0.001235451,0.001685367,0.0004588123,0.00009043772,0.001136559,0.000932239,0.00002217409,0.001561041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953736,"threshold_uncertainty_score":0.009881258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04234992069682217,"score_gpt":0.3830039273369995,"score_spread":0.3406540066401773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}