{"id":"W1546873627","doi":"10.1523/jneurosci.20-21-08005.2000","title":"NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"U.S. Public Health Service; Medical Research Council Canada; ALS Association; Parkinson's Foundation; Heart and Stroke Foundation of Canada; National Alliance for Research on Schizophrenia and Depression; National Institute of Neurological Disorders and Stroke; Medical Research Council; American Heart Association","keywords":"Excitotoxicity; NMDA receptor; Chemistry; Poly ADP ribose polymerase; Neuroscience; Polymerase; Pharmacology; Biochemistry; Biology; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247051,0.0004799588,0.0002554569,0.000136657,0.0001297045,0.0003648301,0.000198826,0.0002237984,0.001614984],"category_scores_gemma":[0.0001550644,0.0001598025,0.0003230947,0.0001193601,0.0001936444,0.0003106668,0.0001410784,0.0005071276,0.000387336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704505,"about_ca_system_score_gemma":0.0001683306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642364,"about_ca_topic_score_gemma":0.0006482939,"domain_scores_codex":[0.9998073,0.00001951662,0.0000223824,0.00006121784,0.0000585356,0.0000311011],"domain_scores_gemma":[0.9998853,0.000008714297,0.00005851828,0.00001516813,0.00001485522,0.00001736112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007881768,0.00002304135,0.0002312477,0.00004577157,0.000009213802,0.00005432833,0.000008207156,0.00002282296,0.9977696,0.0001256271,0.00004127197,0.001590096],"study_design_scores_gemma":[0.00002236814,0.0006695497,0.01360911,0.00001901017,0.0000351808,0.0008070663,0.00003099115,0.0005672405,0.9807692,0.0002170282,0.003248489,0.00000482808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792863,0.005638211,0.01134124,0.0001757573,0.00008206154,0.000064303,0.0006034976,0.0001760684,0.002632619],"genre_scores_gemma":[0.9873857,0.004630529,0.002175098,0.00006206789,0.00001564451,0.00006948927,0.0008808801,0.00002140325,0.004759158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001614984,"threshold_uncertainty_score":0.005402684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411816134597554,"score_gpt":0.306026932632963,"score_spread":0.2819087712869875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}