{"id":"W1546874842","doi":"10.1111/jphp.12053","title":"Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"U.S. National Library of Medicine; Norges Idrettshøgskole; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Glucuronidation; CpG site; DNA methylation; Methylation; Epigenetics; Biology; Genotype; Bilirubin; Molecular biology; Biochemistry; DNA; Gene expression; Endocrinology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065859,0.0001339161,0.0001816545,0.0004212969,0.0001067169,0.0001439663,0.0001148327,0.0001757357,0.001780076],"category_scores_gemma":[0.0006202249,0.0001344577,0.0001239734,0.0002505181,0.0002585344,0.00008357977,0.0001452689,0.0001481455,0.0002156951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004869,"about_ca_system_score_gemma":0.00009039212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009571316,"about_ca_topic_score_gemma":0.0007107015,"domain_scores_codex":[0.9998356,0.0000423277,0.00001221934,0.00006091353,0.00003542235,0.00001346236],"domain_scores_gemma":[0.9995704,0.0001173623,0.0001604989,0.00004860119,0.0000553327,0.00004779535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002380843,0.00005939399,0.4079984,0.0001902162,0.0002184961,0.0003167286,0.0002563949,0.0002621685,0.5705986,0.00009963465,0.0002165282,0.01740259],"study_design_scores_gemma":[0.00001790949,0.0002781817,0.9723178,0.000005976485,0.00005024656,0.000865189,0.00004382838,0.0003125429,0.02552602,0.00008575739,0.0004919519,0.000004703939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971696,0.001303234,0.0007978709,0.000046589,0.000004385449,0.000004520626,0.0003056829,0.00001708192,0.0003510292],"genre_scores_gemma":[0.9987374,0.000275072,0.0004128474,0.00002344831,0.000006760446,0.000008368666,0.000295852,0.000004346603,0.000235818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780076,"threshold_uncertainty_score":0.005954921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1717613400557355,"score_gpt":0.4711815161530852,"score_spread":0.2994201760973496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}