{"id":"W1546936681","doi":"10.1038/onc.2015.136","title":"Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release","year":2015,"lang":"en","type":"article","venue":"Oncogene","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Izaak Walton Killam Health Centre; Toronto Western Hospital; Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Golgi apparatus; Biology; Oncolytic virus; Cell biology; Apoptosis; Programmed cell death; Intracellular; Transfection; Virus; Cell culture; Virology; Endoplasmic reticulum; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006602677,0.0001821867,0.0002213304,0.00007960403,0.00005856879,0.00002303198,0.0002228877,0.0001857877,0.00001307583],"category_scores_gemma":[0.0002830959,0.0001781287,0.00005841829,0.0002515665,0.0001060085,0.000006437282,0.0001764908,0.0001078228,0.0000256287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007973346,"about_ca_system_score_gemma":0.0003935684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007305163,"about_ca_topic_score_gemma":0.00005398916,"domain_scores_codex":[0.998502,0.0001294649,0.000286329,0.0004312937,0.0003250753,0.0003258034],"domain_scores_gemma":[0.9987725,0.000007963024,0.0001036822,0.0004692521,0.0002633893,0.000383228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00190366,0.0001450822,0.00007683037,0.0000217851,0.00006190136,0.000005034189,0.00009376812,0.00002308952,0.9730712,0.00001031912,0.001021266,0.02356612],"study_design_scores_gemma":[0.000848616,0.004357044,0.00002783689,0.00001977922,0.00002628699,0.00001168532,0.00004693355,0.00003392199,0.9805958,0.00007419273,0.0137632,0.0001946855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964921,0.00186382,0.0002793744,0.0002517805,0.00007373825,0.0005706584,0.00008570547,0.00001577458,0.0003670701],"genre_scores_gemma":[0.9981709,0.0001777315,0.0008409215,0.0001099169,0.0002123531,0.00006740806,0.000137627,0.00003250475,0.0002506929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02337143,"threshold_uncertainty_score":0.7263879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02830797628263373,"score_gpt":0.306502975345484,"score_spread":0.2781949990628503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}