{"id":"W1546961109","doi":"10.4137/dti.s378","title":"Recent Advancements in Targeted Delivery of Therapeutic Molecules in Neurodegenerative Disease–-Spinocerebellar Ataxia–-Opportunities and Challenges","year":2008,"lang":"en","type":"article","venue":"Drug Target Insights","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University","keywords":"Medicine; Spinocerebellar ataxia; Disease; Gene silencing; Bioinformatics; Genetic enhancement; Ataxia; Drug discovery; Nanocarriers; Computational biology; Drug; Neuroscience; Gene; Biology; Pharmacology; Genetics; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042478,0.0003881225,0.0006460118,0.0006192807,0.0002348255,0.0007756873,0.0004971943,0.0009306808,0.002979778],"category_scores_gemma":[0.0007946543,0.0001988406,0.0003316591,0.0008586686,0.0005107131,0.001281402,0.0004157727,0.001170109,0.001265159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004621969,"about_ca_system_score_gemma":0.0006765682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762374,"about_ca_topic_score_gemma":0.0005600434,"domain_scores_codex":[0.9997211,0.00006269891,0.00003097079,0.0000574592,0.00009383764,0.00003391519],"domain_scores_gemma":[0.9992211,0.0004099396,0.0000865909,0.00003547496,0.000180132,0.00006675114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003395655,0.0001901209,0.0007950055,0.006700967,0.00005845945,0.0004981408,0.0003226177,0.001754347,0.1229014,0.02183688,0.009635283,0.8349673],"study_design_scores_gemma":[0.00005237824,0.001051586,0.003648485,0.0007357434,0.0002238963,0.004427788,0.0004515838,0.004188238,0.1047874,0.01262949,0.8677288,0.00007466062],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0135998,0.9560586,0.01729013,0.004334129,0.0007073834,0.00002505193,0.0000522712,0.0001186582,0.007814035],"genre_scores_gemma":[0.04592551,0.9342711,0.01193533,0.001135291,0.00105199,0.00003777875,0.0001153726,0.00002322195,0.005504466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002979778,"threshold_uncertainty_score":0.0099684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04820452856902558,"score_gpt":0.2393625561885666,"score_spread":0.191158027619541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}