{"id":"W1546961109","doi":"10.4137/dti.s378","title":"Recent Advancements in Targeted Delivery of Therapeutic Molecules in Neurodegenerative Disease–-Spinocerebellar Ataxia–-Opportunities and Challenges","year":2008,"lang":"en","type":"article","venue":"Drug Target Insights","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University","keywords":"Medicine; Spinocerebellar ataxia; Disease; Gene silencing; Bioinformatics; Genetic enhancement; Ataxia; Drug discovery; Nanocarriers; Computational biology; Drug; Neuroscience; Gene; Biology; Pharmacology; Genetics; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006469794,0.0002126391,0.0002392353,0.0001469475,0.00005007132,0.000005852197,0.0001538804,0.00007322121,0.00001908838],"category_scores_gemma":[0.00001753806,0.0001996864,0.00004583246,0.00008880685,0.000139166,0.00001794348,0.0000968989,0.00008710138,0.00000193069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001659491,"about_ca_system_score_gemma":0.0001073308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003247454,"about_ca_topic_score_gemma":0.0002057819,"domain_scores_codex":[0.9987534,0.0001504525,0.0003190128,0.0004027886,0.0001469872,0.0002273323],"domain_scores_gemma":[0.9994453,0.00001278255,0.0000972979,0.0002546984,0.0001022913,0.00008759955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003717553,0.002871177,0.1027488,0.0006910856,0.000554974,0.0013105,0.01601547,0.004691972,0.7947614,0.002343263,0.002279547,0.06801423],"study_design_scores_gemma":[0.002908694,0.0007640554,0.1422173,0.0001622457,0.000033989,0.00001933037,0.002591694,0.001357394,0.7000107,0.001224027,0.1476054,0.001105164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8659911,0.1331246,0.00002163481,0.0002332409,0.00008250815,0.0001746485,0.00002769203,0.00000570011,0.0003389343],"genre_scores_gemma":[0.7560316,0.2432626,0.0001221349,0.0002519607,0.00002936789,0.00002304797,0.0001275663,0.00001485174,0.0001367815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1453259,"threshold_uncertainty_score":0.8142973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04820452856902558,"score_gpt":0.2393625561885666,"score_spread":0.191158027619541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}