{"id":"W1547102031","doi":"10.1111/cge.12385","title":"Personalized gene silencing therapeutics for Huntington disease","year":2014,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"U.S. Public Health Service","keywords":"Gene silencing; Huntingtin; Genetics; Biology; Huntington's disease; Trinucleotide repeat expansion; Allele; Population; Linkage disequilibrium; Single-nucleotide polymorphism; Disease; Gene; Genotype; Medicine; Mutant; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004108897,0.0007475747,0.001016536,0.001926167,0.0002472367,0.0006623385,0.000747157,0.0009569922,0.003390512],"category_scores_gemma":[0.0004236323,0.0002358473,0.0004801171,0.001241513,0.0003183441,0.0009379239,0.0006216339,0.001601008,0.002294905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005243286,"about_ca_system_score_gemma":0.0005643409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007087127,"about_ca_topic_score_gemma":0.001519754,"domain_scores_codex":[0.9998838,0.00001851607,0.00001610119,0.00001794646,0.00005118832,0.00001247258],"domain_scores_gemma":[0.9998722,0.00005624591,0.00001822794,0.000005137384,0.00003550048,0.00001262212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005708107,0.00008572341,0.00009069718,0.01187179,0.00008166815,0.0002328445,0.00004950033,0.0003262907,0.003074553,0.004099675,0.02573686,0.9542933],"study_design_scores_gemma":[0.00001991846,0.00008050751,0.0004030416,0.001913343,0.00007875882,0.001143761,0.00002597658,0.00009038712,0.0008429957,0.001770489,0.9936178,0.00001303236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001970694,0.9975673,0.0002388379,0.00018811,0.0001621682,0.000008386272,0.00002364558,0.00001453037,0.001599986],"genre_scores_gemma":[0.0008926241,0.9977003,0.0002386054,0.0001696879,0.00006711772,0.00001016119,0.00004099382,0.000002502247,0.0008780104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003390512,"threshold_uncertainty_score":0.01134241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2973280956183884,"score_gpt":0.4708379602253325,"score_spread":0.1735098646069441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}