{"id":"W1547102031","doi":"10.1111/cge.12385","title":"Personalized gene silencing therapeutics for Huntington disease","year":2014,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"U.S. Public Health Service","keywords":"Gene silencing; Huntingtin; Genetics; Biology; Huntington's disease; Trinucleotide repeat expansion; Allele; Population; Linkage disequilibrium; Single-nucleotide polymorphism; Disease; Gene; Genotype; Medicine; Mutant; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006912893,0.0008696855,0.002373366,0.0001316985,0.0002919801,0.0001712564,0.001267775,0.0004407859,0.000059801],"category_scores_gemma":[0.00418258,0.0007435025,0.002285468,0.0003170548,0.0006289352,0.00002815469,0.0003304724,0.0005625624,0.0002205459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005130761,"about_ca_system_score_gemma":0.0008477712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.669431e-7,"about_ca_topic_score_gemma":4.049687e-7,"domain_scores_codex":[0.9931105,0.001588295,0.002021511,0.001921029,0.0005695254,0.0007891562],"domain_scores_gemma":[0.9913871,0.005310589,0.001023593,0.001400182,0.0001742774,0.0007042364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004827539,0.0003804677,0.00005005873,0.006967274,0.00008064957,0.000007149482,0.00002032704,0.00002669679,0.0003959139,0.0002876771,0.0007069315,0.9910286],"study_design_scores_gemma":[0.0006100899,0.0002653964,0.00002289288,0.001217461,0.002444491,0.000002542891,0.000002571397,0.0004325471,0.002563091,0.0003060576,0.9913055,0.0008273146],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002034115,0.9897695,0.002829134,0.00005824983,0.002146705,0.002376989,0.0005619447,0.0001369239,0.00008645061],"genre_scores_gemma":[0.0002769514,0.991632,0.001853629,0.002565681,0.001961361,0.0003842714,0.0001002373,0.000277436,0.0009484491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905986,"threshold_uncertainty_score":0.9995016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2973280956183884,"score_gpt":0.4708379602253325,"score_spread":0.1735098646069441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}