{"id":"W1547750496","doi":"10.1038/leu.2015.155","title":"Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer","year":2015,"lang":"en","type":"article","venue":"Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"University of Warwick; Uehara Memorial Foundation; Fujita Health University; Takeda Science Foundation","keywords":"Cytotoxic T cell; CD8; Biology; Interleukin 21; Adoptive cell transfer; Leukemia; T-cell receptor; T cell; Natural killer T cell; Interleukin 3; Immunotherapy; Cancer research; Interleukin 12; Streptamer; ZAP70; Immunology; Molecular biology; Antigen; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739534,0.0004049388,0.0002131746,0.0002696889,0.0001191371,0.0003255773,0.0001741447,0.0002699654,0.00103452],"category_scores_gemma":[0.00008894206,0.0001466862,0.0001568618,0.0001029795,0.0002011771,0.0001803237,0.0001623279,0.0004535554,0.0002780485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645771,"about_ca_system_score_gemma":0.0001444754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149755,"about_ca_topic_score_gemma":0.0002316018,"domain_scores_codex":[0.9998593,0.00003284779,0.00001139731,0.000026857,0.00001917166,0.00005036144],"domain_scores_gemma":[0.9999194,0.00001801068,0.00002371178,0.00001142773,0.000007574672,0.00001974765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594823,0.0000249715,0.00007186495,0.00001089281,0.000002081317,0.00002938447,0.00001055973,0.0001167903,0.9985774,0.000156316,0.00001593283,0.0008243736],"study_design_scores_gemma":[0.00005249515,0.0003314785,0.0007422988,0.000001888331,0.00001964618,0.0001559903,0.00001052189,0.001152587,0.9961717,0.00005264927,0.001305672,0.00000324228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968836,0.0003589566,0.001669418,0.00004271535,0.00001805521,0.00001703085,0.00006456521,0.00005870858,0.0008870164],"genre_scores_gemma":[0.9980565,0.0001497359,0.0008352922,0.00001490842,0.00000842328,0.00001351699,0.00007527031,0.00001329761,0.0008330579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103452,"threshold_uncertainty_score":0.003460824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644519815614984,"score_gpt":0.2563900247631855,"score_spread":0.2299448266070356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}