{"id":"W1547750496","doi":"10.1038/leu.2015.155","title":"Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer","year":2015,"lang":"en","type":"article","venue":"Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"University of Warwick; Uehara Memorial Foundation; Fujita Health University; Takeda Science Foundation","keywords":"Cytotoxic T cell; CD8; Biology; Interleukin 21; Adoptive cell transfer; Leukemia; T-cell receptor; T cell; Natural killer T cell; Interleukin 3; Immunotherapy; Cancer research; Interleukin 12; Streptamer; ZAP70; Immunology; Molecular biology; Antigen; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003715038,0.0003132416,0.0005594492,0.0001706444,0.00004681193,0.0000303469,0.0001874807,0.0003473606,0.001284689],"category_scores_gemma":[0.00006505975,0.000291111,0.0001424202,0.000470844,0.0002591075,0.00006419694,0.00005198455,0.0005387234,0.00008805425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008080205,"about_ca_system_score_gemma":0.0008571912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001815632,"about_ca_topic_score_gemma":0.000003743574,"domain_scores_codex":[0.9974009,0.0001392115,0.0005555378,0.0005673342,0.0008337036,0.0005033494],"domain_scores_gemma":[0.9981261,0.0002110294,0.00005250647,0.0005797623,0.0004070975,0.0006234589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001165597,0.0001689061,0.0008392044,0.0001085047,0.00008126498,0.00001830152,0.0002345218,0.000100998,0.953159,0.0000224969,0.04001507,0.004086137],"study_design_scores_gemma":[0.007645532,0.0005733698,0.003737936,0.0000354881,0.00006342822,0.00002618569,0.00006882234,0.002231062,0.8660703,0.00001970601,0.1192418,0.0002864082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919972,0.00164989,0.001885703,0.0001739949,0.0002968061,0.0007102079,0.0001564252,0.00009348026,0.003036274],"genre_scores_gemma":[0.9855177,0.001090562,0.00277626,0.0001548995,0.0003065634,0.00003393638,0.0002462537,0.00008539842,0.0097884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08708873,"threshold_uncertainty_score":0.9999541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644519815614984,"score_gpt":0.2563900247631855,"score_spread":0.2299448266070356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}