{"id":"W1547792216","doi":"","title":"REVIEW ARTICLE: APPLICATION OF CELL-BASED ASSAY SYSTEMS FOR THE EARLY SCREENING OF HUMAN DRUG HEPATOTOXICITY IN THE DISCOVERY PHASE OF DRUG DEVELOPMENT","year":2005,"lang":"en","type":"article","venue":"Iranian journal of pharmaceutical research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Phospholipidosis; Drug; Pharmacology; Drug discovery; Drug development; In vivo; Medicine; Bioinformatics; Chemistry; Biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02764162,0.0001936016,0.0005582236,0.0003027896,0.0003374868,0.00003067397,0.0009111034,0.0001502079,0.00005520756],"category_scores_gemma":[0.0005252124,0.0001280513,0.0002464767,0.0007995681,0.0004805296,0.0002654316,0.00006918581,0.001983808,0.000004544803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374727,"about_ca_system_score_gemma":0.0003489553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007452804,"about_ca_topic_score_gemma":0.00003091774,"domain_scores_codex":[0.9930967,0.003550221,0.001625291,0.0002178024,0.0009905978,0.0005193889],"domain_scores_gemma":[0.9937393,0.004222798,0.0007753512,0.000280061,0.0007934793,0.0001889965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003523595,0.004811083,0.01034028,0.006707241,0.0003451895,0.0000160872,0.005332567,0.003685768,0.8682286,0.001089144,0.001377332,0.09454316],"study_design_scores_gemma":[0.005589895,0.0003670366,0.001106112,0.001105959,0.0002218064,0.000016373,0.0006262751,0.03154149,0.9300897,0.0001113329,0.02905193,0.0001721507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672415,0.01164936,0.01546915,0.00248989,0.0001531366,0.002773179,0.00004923033,0.000006715198,0.0001678445],"genre_scores_gemma":[0.9976619,0.001162039,0.0003461925,0.000401912,0.00020991,0.000156135,0.000003619848,0.00002033965,0.0000378993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09437101,"threshold_uncertainty_score":0.9580089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3250981567425697,"score_gpt":0.5415104293653934,"score_spread":0.2164122726228237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}