{"id":"W1547792216","doi":"","title":"REVIEW ARTICLE: APPLICATION OF CELL-BASED ASSAY SYSTEMS FOR THE EARLY SCREENING OF HUMAN DRUG HEPATOTOXICITY IN THE DISCOVERY PHASE OF DRUG DEVELOPMENT","year":2005,"lang":"en","type":"article","venue":"Iranian journal of pharmaceutical research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Phospholipidosis; Drug; Pharmacology; Drug discovery; Drug development; In vivo; Medicine; Bioinformatics; Chemistry; Biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066019,0.0009765569,0.001378208,0.002056152,0.0004039603,0.00142131,0.00070565,0.001308981,0.006480307],"category_scores_gemma":[0.0009501328,0.0002409471,0.0003891202,0.002434844,0.0005560695,0.001391819,0.0005073715,0.001099086,0.006775836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000472694,"about_ca_system_score_gemma":0.0006481966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005297129,"about_ca_topic_score_gemma":0.0007469513,"domain_scores_codex":[0.9993211,0.0001483773,0.00006577576,0.0001164487,0.0003101436,0.00003819966],"domain_scores_gemma":[0.9990748,0.000326202,0.00009613149,0.00004476771,0.0004046294,0.00005345427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000265863,0.0002854368,0.001192316,0.01340104,0.00008715329,0.0008236892,0.000144921,0.000409409,0.1305043,0.002246029,0.04176047,0.8088794],"study_design_scores_gemma":[0.00004256934,0.0007534457,0.003921871,0.001030953,0.0001619152,0.007641341,0.0001646123,0.0004050635,0.07036964,0.00111582,0.9143386,0.00005422093],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004948188,0.9667132,0.008715295,0.00157086,0.004334617,0.0001781126,0.0003202473,0.0001424486,0.01307695],"genre_scores_gemma":[0.01977042,0.9470593,0.01401168,0.001323401,0.00307698,0.0001416121,0.00055216,0.00005900467,0.01400547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006480307,"threshold_uncertainty_score":0.02167881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3250981567425697,"score_gpt":0.5415104293653934,"score_spread":0.2164122726228237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}