{"id":"W1547880281","doi":"10.1038/bjc.2015.220","title":"BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts","year":2015,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; Ontario Ministry of Health and Long-Term Care; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Gemcitabine; Pancreatic cancer; Cisplatin; Medicine; Oncology; Cancer research; Internal medicine; Chemotherapy; BRCA mutation; Germline mutation; Cancer; Germline; Mutation; Ovarian cancer; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005107024,0.0002871885,0.0005383822,0.0002538767,0.0001926403,0.0005417804,0.0002731932,0.0004214491,0.002459127],"category_scores_gemma":[0.0007668809,0.0002359857,0.0003110262,0.0003787515,0.0001995114,0.0003197652,0.0002754797,0.0009469092,0.0005500029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003729373,"about_ca_system_score_gemma":0.0002136436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005727505,"about_ca_topic_score_gemma":0.0006892275,"domain_scores_codex":[0.9996744,0.0001077115,0.00004677976,0.00004992695,0.0000835644,0.00003753486],"domain_scores_gemma":[0.9992514,0.0003377647,0.00009577665,0.0001461275,0.00007102788,0.00009785642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001157268,0.0005494591,0.01754349,0.0001575253,0.0001077377,0.000871824,0.0003059624,0.001758893,0.9723741,0.0003243037,0.0006421338,0.004207287],"study_design_scores_gemma":[0.0002459142,0.009144914,0.1097775,0.00005872458,0.0002342382,0.0172436,0.0004386959,0.007249164,0.8442063,0.0003474107,0.01101563,0.00003784074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971282,0.0006129303,0.0007048973,0.00005285288,0.0000138088,0.00004751615,0.0004517178,0.000030922,0.0009572009],"genre_scores_gemma":[0.9958133,0.0006350903,0.001351592,0.0000521675,0.000005802063,0.00004273791,0.001371772,0.00002403143,0.0007034698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002459127,"threshold_uncertainty_score":0.008226633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03079712940837903,"score_gpt":0.3547631851238908,"score_spread":0.3239660557155117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}