{"id":"W1548282121","doi":"10.1074/jbc.m011031200","title":"Epidermal Growth Factor Induction of Apolipoprotein A-I Is Mediated by the Ras-MAP Kinase Cascade and Sp1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Promotion and Mutual Aid Corporation for Private Schools of Japan; Heart and Stroke Foundation of Canada; Fondation pour la Recherche Médicale; AstraZeneca","keywords":"Cascade; Epidermal growth factor; Factor (programming language); Cancer research; Kinase; Biology; Internal medicine; Cell biology; Chemistry; Medicine; Computer science; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002680571,0.000140559,0.0002094161,0.00001672429,0.00005983233,0.00001370795,0.0001580744,0.000286288,0.0001220873],"category_scores_gemma":[0.0003364781,0.00008491,0.0001211257,0.00007594755,0.0001946284,0.000007177646,0.0000623145,0.0002154958,8.807999e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001376887,"about_ca_system_score_gemma":0.0000396846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001214114,"about_ca_topic_score_gemma":3.264869e-7,"domain_scores_codex":[0.9990516,0.00006806533,0.0003993175,0.0001632713,0.0001534273,0.0001642674],"domain_scores_gemma":[0.9991691,0.00003244187,0.0003928431,0.0001252831,0.000162528,0.0001178406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143226,0.00004922331,0.001651381,0.00002339133,0.00004216887,0.000008763422,0.00002048181,0.000001626338,0.9955941,0.00000356008,0.0009329945,0.001529059],"study_design_scores_gemma":[0.0005344221,0.0001519647,0.001629017,0.00002538197,0.00001319138,0.0002655672,0.00008797571,0.00001057871,0.9880173,0.0001241495,0.009031325,0.0001091732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946448,0.003612858,0.0003544934,0.001141424,0.00003664993,0.00008113854,0.0000336388,0.000003842778,0.00009116524],"genre_scores_gemma":[0.9985185,0.0006339994,0.0001417243,0.0002340103,0.0003342799,0.00000217465,0.00003178011,0.000007095225,0.00009639176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00809833,"threshold_uncertainty_score":0.3462529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970756000629384,"score_gpt":0.2509930451978319,"score_spread":0.231285485191538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}