{"id":"W1548319599","doi":"10.1186/ar1344","title":"Transcriptional regulation of the mPGES-1 gene in primary cultured articular chondrocytes","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Molecular biology; Gene isoform; Prostaglandin E2; Messenger RNA; Transfection; Oligonucleotide; Chemistry; Ccaat-enhancer-binding proteins; Binding site; Prostaglandin; Expression vector; Enhancer; Biology; Recombinant DNA; Gene expression; Cell biology; Transcription factor; Gene; Biochemistry; DNA-binding protein; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007754799,0.00007493,0.0001788601,0.0001363689,0.00009112347,0.00000971619,0.0000877181,0.00008822668,0.00008154801],"category_scores_gemma":[0.0001833972,0.0000534526,0.00008625205,0.000447952,0.0002095509,0.00008671283,0.00002739639,0.0003206235,0.00003165625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609294,"about_ca_system_score_gemma":0.0002665873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007031771,"about_ca_topic_score_gemma":0.0001203674,"domain_scores_codex":[0.9983433,0.0001543366,0.0002401033,0.0001721005,0.0008052603,0.0002848852],"domain_scores_gemma":[0.999414,0.00005194424,0.00002706722,0.0002457715,0.0001808215,0.00008039306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001937458,0.0001802954,0.01130735,0.000102982,0.00001441719,0.00006450441,0.0008041714,0.0001398432,0.9802197,0.001904661,0.0002718458,0.004796541],"study_design_scores_gemma":[0.003106108,0.0001534331,0.6020855,0.0003915664,0.000003935466,0.00006049626,0.000044924,0.0000336103,0.3914713,0.001201576,0.001392702,0.00005482581],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994881,0.002186374,0.00003435836,0.001218657,0.0001009523,0.0005761777,0.000004791563,0.00001249686,0.0009851289],"genre_scores_gemma":[0.9988111,0.0003512587,0.0003516581,0.00008134848,0.00013236,0.00005003252,0.00002018046,0.00001170364,0.0001903706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5907782,"threshold_uncertainty_score":0.2179734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403989646093207,"score_gpt":0.2960435938755205,"score_spread":0.2720036974145885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}