{"id":"W1548328806","doi":"10.1016/j.bone.2015.08.020","title":"The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants","year":2015,"lang":"en","type":"article","venue":"Bone","topic":"Bone health and treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Biotechnology and Biological Sciences Research Council; Medical Research Council; Versus Arthritis; Ministero dello Sviluppo Economico; Rosetrees Trust; Sanofi; Bayer HealthCare; Ontario Ministry of Economic Development and Innovation; National Institute for Health and Care Research; Diamond Light Source; Wellcome Trust; Genome Canada; University of Rochester; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Farnesyl pyrophosphate; Active site; Chemistry; Stereochemistry; Threonine; Pyrophosphate; Binding site; Enzyme; Tyrosine; Biochemistry; Mutant; Residue (chemistry); ATP synthase; Serine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005156116,0.0001873956,0.0003929172,0.00005155505,0.0003061478,0.00001816143,0.00004911196,0.00008310054,0.00001250391],"category_scores_gemma":[0.0001893656,0.0001152263,0.00005236875,0.0002078342,0.0002326409,0.0001188822,0.00007219266,0.0001741424,0.000003042009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019661,"about_ca_system_score_gemma":0.0001585895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005684305,"about_ca_topic_score_gemma":0.0002994845,"domain_scores_codex":[0.9985713,0.00007587962,0.0004768506,0.0002293639,0.0003196519,0.0003269605],"domain_scores_gemma":[0.998706,0.0001421346,0.0004464925,0.0002900988,0.000236826,0.0001783954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004594815,0.0006361268,0.1177389,0.000158918,0.0003907874,0.00009145511,0.005224695,0.0000162523,0.8303223,0.0006376134,0.000350998,0.03983718],"study_design_scores_gemma":[0.004188971,0.0008190857,0.007787788,0.0003881352,0.0002305141,0.00006135779,0.002666053,0.0005672062,0.9817502,0.001103258,0.0003033295,0.0001341133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719278,0.02691002,0.00001373572,0.000274749,0.00004306664,0.0004942168,0.00008294412,0.00002082853,0.0002326221],"genre_scores_gemma":[0.9992269,0.0002039338,0.000237246,0.00007620873,0.00002646669,0.00001894131,0.0000504799,0.00003007057,0.0001297382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1514279,"threshold_uncertainty_score":0.8593007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219175138421533,"score_gpt":0.2886974370992,"score_spread":0.2665056857149847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}