{"id":"W1548741427","doi":"10.1074/jbc.m011240200","title":"Enhanced Antiviral and Antiproliferative Properties of a STAT1 Mutant Unable to Interact with the Protein Kinase PKR","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Protein kinase R; STAT1; Phosphorylation; Protein kinase A; Biology; Kinase; EIF-2 kinase; Cell biology; Molecular biology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394847,0.0001070332,0.0001626145,0.00001165393,0.00003910147,0.00001982133,0.0001166429,0.00006642058,0.00001516619],"category_scores_gemma":[0.0001396479,0.00005037246,0.0000552802,0.00006691601,0.0001514134,0.00000650517,0.00005349467,0.0000860654,3.711939e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009731513,"about_ca_system_score_gemma":0.00008090455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001343891,"about_ca_topic_score_gemma":7.721913e-7,"domain_scores_codex":[0.9993857,0.00003992159,0.0002101414,0.0001333768,0.0001007737,0.0001300931],"domain_scores_gemma":[0.9994387,0.000006975861,0.0001861926,0.0001079073,0.0001649396,0.00009528577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00164832,0.00009054246,0.001706739,0.00001760526,0.0000366824,0.00002281569,0.00005715469,0.00001949587,0.9955953,0.000003459379,0.00003558187,0.0007663057],"study_design_scores_gemma":[0.0005009302,0.0004766524,0.002367895,0.00005879227,0.000009484446,0.00009686669,0.000303311,0.000009538507,0.9946524,0.00001212586,0.001426166,0.00008585027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982362,0.000404697,0.0004530755,0.0004388853,0.000008338645,0.0001521123,0.000005577855,0.000002225862,0.0002988362],"genre_scores_gemma":[0.9992406,0.0000510108,0.0001407826,0.0001382259,0.00009003731,0.000009584484,0.000002816621,0.000004817681,0.0003221286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390584,"threshold_uncertainty_score":0.2054129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391621416635291,"score_gpt":0.2413070825565573,"score_spread":0.2273908683902044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}