{"id":"W1549021899","doi":"10.1034/j.1399-0004.2000.580101.x","title":"Improvements in adenoviral vector technology: overcoming barriers for gene therapy","year":2000,"lang":"en","type":"review","venue":"Clinical Genetics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Medical Research Council; Medical Research Council Canada; Ottawa Hospital Research Institute","keywords":"Genetic enhancement; Viral vector; Vector (molecular biology); Gene transfer; Medicine; Gene; Computational biology; Genetics; Biology; Bioinformatics; Cancer research; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001028282,0.0006141251,0.001490698,0.0002764868,0.0000999511,0.00004324272,0.001179662,0.001826504,0.00008477036],"category_scores_gemma":[0.0003386607,0.00056398,0.0008843455,0.000413667,0.0003496646,0.000002439981,0.0002611978,0.0007483647,0.00003876534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007421804,"about_ca_system_score_gemma":0.001133182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002160925,"about_ca_topic_score_gemma":0.0000273047,"domain_scores_codex":[0.9958505,0.0003465977,0.001483116,0.001231818,0.0002509129,0.000837073],"domain_scores_gemma":[0.9978519,0.000139587,0.000330811,0.001303197,0.00009672617,0.0002777961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006462084,0.0001405771,0.0001503887,0.0004212602,0.0003043149,0.000006366665,0.000004333195,0.000004946162,0.0012029,0.000001812041,0.0004895256,0.9966274],"study_design_scores_gemma":[0.001981196,0.005521091,0.000008743816,0.0003923797,0.00009828491,0.000005351443,0.000005920451,0.00001588885,0.003481915,0.00008053899,0.9878132,0.0005954992],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01912666,0.9777619,0.00004542734,0.0000425923,0.0003997297,0.002305711,0.0002409397,0.00002622949,0.0000507903],"genre_scores_gemma":[0.0003448417,0.9956169,0.0009701926,0.0003197161,0.0009550208,0.0005964834,0.0004297234,0.0001998852,0.0005672956],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9960319,"threshold_uncertainty_score":0.9996812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09014785042760552,"score_gpt":0.4453028488339859,"score_spread":0.3551549984063804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}