{"id":"W1549522748","doi":"10.1016/j.eururo.2015.04.032","title":"Impact of Bone-targeted Therapies in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate: Post Hoc Analysis of Study COU-AA-302","year":2015,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Alberta Cancer Foundation; Université de Montréal","funders":"National Cancer Institute","keywords":"Medicine; Abiraterone acetate; Concomitant; Prednisone; Prostate cancer; Interim analysis; Post-hoc analysis; Hazard ratio; Internal medicine; Oncology; Placebo; Cancer; Urology; Surgery; Androgen deprivation therapy; Clinical trial; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004341119,0.0002631265,0.0008545764,0.000642557,0.00002865842,0.00001203002,0.0001014321,0.00002972316,0.0001334299],"category_scores_gemma":[0.00003580929,0.0001608451,0.000120294,0.001144017,0.0002196964,0.00008436336,0.00002880247,0.0001527674,0.000005252388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631675,"about_ca_system_score_gemma":0.0002988907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001452731,"about_ca_topic_score_gemma":0.0009378107,"domain_scores_codex":[0.9977434,0.0005889793,0.0005709191,0.0003621748,0.0003776924,0.0003568598],"domain_scores_gemma":[0.9984579,0.00005305828,0.0003283806,0.0003329079,0.0006766782,0.0001510379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02771699,0.002533919,0.934388,0.00003614661,0.006352819,0.0003006781,0.01200595,0.0006341963,0.01472774,8.209795e-7,0.00005463081,0.001248129],"study_design_scores_gemma":[0.01754834,0.02320549,0.9561471,0.00001873178,0.001287757,0.00000295077,0.0007661652,0.0001601545,0.0007162569,0.000001611428,0.00001601088,0.0001294578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996915,0.001151032,0.000001525767,0.0001879717,0.00001864917,0.001279855,0.0002448586,0.00002196951,0.000179118],"genre_scores_gemma":[0.9991216,0.0001493641,0.00003883131,0.00005237565,0.00001016674,0.00004265505,0.0003085747,0.00004960698,0.0002268279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02175909,"threshold_uncertainty_score":0.6559073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02907524792620767,"score_gpt":0.3280388085479521,"score_spread":0.2989635606217444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}