{"id":"W1550192924","doi":"10.4049/jimmunol.174.1.180","title":"CD28 Regulates the Translation of Bcl-xL via the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Pathway","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"CD28; Polysome; Translation (biology); Cell biology; PI3K/AKT/mTOR pathway; Phosphorylation; Phosphatidylinositol; Signal transduction; Biology; T-cell receptor; Messenger RNA; Kinase; Chemistry; Molecular biology; T cell; Gene; Biochemistry; Ribosome; RNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026173,0.0002609285,0.0001173024,0.000192401,0.0002018373,0.0003232617,0.00009409007,0.0001387726,0.001193602],"category_scores_gemma":[0.0001518715,0.00009422187,0.0001225443,0.00007056441,0.0002628391,0.0001424981,0.0002349343,0.0004236468,0.0005820764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004418955,"about_ca_system_score_gemma":0.0002178759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003069323,"about_ca_topic_score_gemma":0.0005207371,"domain_scores_codex":[0.9998883,0.00002673359,0.000005508791,0.00001823583,0.00002386758,0.00003740138],"domain_scores_gemma":[0.9999043,0.00001749598,0.00002534024,0.000006931786,0.00001231132,0.0000336503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001327013,0.00002065037,0.0001680693,0.00001883083,0.000001830697,0.00004227872,0.000008609832,0.00007503526,0.9975364,0.0001829728,0.00008844156,0.001724223],"study_design_scores_gemma":[0.00005876525,0.0002311827,0.007746933,0.000005999647,0.000008398068,0.0002618896,0.00004701771,0.002776609,0.9851489,0.000286048,0.003423545,0.000004614871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916413,0.002986595,0.002130101,0.0002833019,0.00004126339,0.00001286332,0.0001165981,0.0001075097,0.002680525],"genre_scores_gemma":[0.9966714,0.000671809,0.001086751,0.00004322731,0.00001302587,0.00001002306,0.0001201614,0.00001248178,0.001371109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193602,"threshold_uncertainty_score":0.003993034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009354194654807297,"score_gpt":0.2150958821112394,"score_spread":0.2057416874564321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}