{"id":"W1550376883","doi":"10.1002/path.4230","title":"Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling","year":2013,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":434,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Biology; Serous fluid; Ovarian cancer; Copy number analysis; Amplicon; Fallopian tube; Copy-number variation; Somatic evolution in cancer; Exome; Exome sequencing; Germline mutation; Genetics; Mutation; Gene; Cancer; Genome; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307022,0.00009221927,0.000143704,0.0005935302,0.0001580234,0.0003217643,0.0001078101,0.0001388268,0.0004634525],"category_scores_gemma":[0.0004971545,0.0001087879,0.0001216769,0.000398397,0.0001928774,0.0001230077,0.0002858712,0.0001481444,0.0001262336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045128,"about_ca_system_score_gemma":0.00008916762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128866,"about_ca_topic_score_gemma":0.002274059,"domain_scores_codex":[0.9998935,0.00001659786,0.00000607115,0.00003210336,0.0000281452,0.00002357421],"domain_scores_gemma":[0.9998189,0.00004941792,0.00005705772,0.00001941249,0.0000316903,0.00002356477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005318464,0.00003060433,0.54436,0.00006744178,0.00006314384,0.001083836,0.0007897788,0.00156278,0.4310797,0.0002669354,0.0001017652,0.02006218],"study_design_scores_gemma":[0.000003547297,0.0001032157,0.9700947,0.000005287475,0.00002129873,0.002304342,0.0003402719,0.00257075,0.02366575,0.0001486176,0.0007347214,0.000007559409],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990053,0.0001588299,0.0004989084,0.000008094422,4.256401e-7,0.000004255299,0.0000951537,0.000007359134,0.0002217],"genre_scores_gemma":[0.999117,0.00009530902,0.0004436102,0.00000731915,8.803511e-7,0.000006911739,0.0001833379,0.00000453541,0.000141167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128866,"threshold_uncertainty_score":0.002244592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066927604908341,"score_gpt":0.2371437835386869,"score_spread":0.2264745074896035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}