{"id":"W1550568565","doi":"10.1111/j.1462-5822.2010.01433.x","title":"Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B","year":2010,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Office of the Higher Education Commission; National Institutes of Health","keywords":"Zymogen; Opisthorchis viverrini; Cathepsin L; Biochemistry; Proteases; Biology; Cathepsin; Cysteine protease; Cathepsin B; Liver fluke; Enzyme; Opisthorchiasis; Secretion; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007924921,0.0002177146,0.0001184772,0.0001065951,0.0001023266,0.0002062633,0.00006287337,0.0001704061,0.0003449247],"category_scores_gemma":[0.0001239505,0.0000654461,0.0001308318,0.00005681178,0.0001454372,0.000154048,0.0001172043,0.0001897259,0.00008336596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004443,"about_ca_system_score_gemma":0.0001108759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000943836,"about_ca_topic_score_gemma":0.001143465,"domain_scores_codex":[0.9999425,0.000008142777,0.000004453163,0.00001066273,0.000009707171,0.00002460787],"domain_scores_gemma":[0.9999397,0.000008084897,0.00002410429,0.000003523659,0.000009152202,0.00001543917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000852985,0.000007919656,0.0007846879,0.00001629923,0.000002116424,0.00005398062,0.00002119042,0.00001817912,0.9984522,0.00002109079,0.00001042243,0.000526557],"study_design_scores_gemma":[0.00002563086,0.0005091118,0.125428,0.000008532745,0.00001938633,0.001202374,0.0001895234,0.001296513,0.8695586,0.00006823798,0.001685176,0.000008927898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987729,0.000645149,0.0002836442,0.00002775365,0.000003309615,0.00000440548,0.00004721131,0.000005786699,0.0002098472],"genre_scores_gemma":[0.9986535,0.0003096643,0.0003667279,0.0000145918,0.000002867121,0.000006014545,0.0001181166,0.000002162789,0.0005263181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000943836,"threshold_uncertainty_score":0.001876712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005587881188481168,"score_gpt":0.2069044589490816,"score_spread":0.2013165777606004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}