{"id":"W1550568565","doi":"10.1111/j.1462-5822.2010.01433.x","title":"Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B","year":2010,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Office of the Higher Education Commission; National Institutes of Health","keywords":"Zymogen; Opisthorchis viverrini; Cathepsin L; Biochemistry; Proteases; Biology; Cathepsin; Cysteine protease; Cathepsin B; Liver fluke; Enzyme; Opisthorchiasis; Secretion; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157959,0.0001942656,0.0003515045,0.00009811433,0.0002006492,0.000007101025,0.0002315815,0.0003726013,0.0003217138],"category_scores_gemma":[0.00005114811,0.0001508391,0.0001337474,0.0001827243,0.0006028324,0.00008653557,0.00005999272,0.0003492117,0.00001068509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002842036,"about_ca_system_score_gemma":0.00006828287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008655758,"about_ca_topic_score_gemma":0.0001057877,"domain_scores_codex":[0.9987975,0.0002236404,0.0004078519,0.0003228318,0.00002227212,0.0002258978],"domain_scores_gemma":[0.9990236,0.00009606109,0.000389619,0.0003420123,0.0001285399,0.00002017085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009314221,0.0001100197,0.001714877,0.0000526587,0.0001128245,1.982351e-7,0.0007922067,0.000002060893,0.9949858,0.00005874702,0.0006635745,0.001413955],"study_design_scores_gemma":[0.0005914958,0.0001140636,0.002878226,0.00003986209,0.0001333019,0.00006740511,0.00007704484,0.00004194024,0.9773428,0.00001774573,0.01855152,0.0001445777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947137,0.00289612,0.001116246,0.0001507066,0.0002041206,0.0004060561,0.0004107884,0.00002196051,0.00008029057],"genre_scores_gemma":[0.9969243,0.00003130479,0.0001067729,0.00003171054,0.00001423118,0.00002015944,0.00113322,0.00001754325,0.001720726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01788794,"threshold_uncertainty_score":0.615104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005587881188481168,"score_gpt":0.2069044589490816,"score_spread":0.2013165777606004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}