{"id":"W1550732900","doi":"10.1002/stem.1659","title":"Switch from Canonical to Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis","year":2014,"lang":"en","type":"article","venue":"Stem Cells","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Lawson Health Research Institute; National Eye Institute; Michigan State University; National Institutes of Health; College of Engineering, Michigan State University; Canadian Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Adipogenesis; Biology; Wnt signaling pathway; Progenitor cell; Mesenchymal stem cell; Cell biology; Stem cell; Bone marrow; Cellular differentiation; Multipotent Stem Cell; Endocrinology; Cancer research; Signal transduction; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001105397,0.0003916818,0.0008959895,0.000195209,0.0001416595,0.00007557902,0.0004591871,0.0003500922,0.001698846],"category_scores_gemma":[0.0001913354,0.0003281666,0.0002226955,0.0004973008,0.00006679164,0.00006187017,0.0002854583,0.0005168104,0.003217051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293588,"about_ca_system_score_gemma":0.000609012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002410723,"about_ca_topic_score_gemma":0.0002968461,"domain_scores_codex":[0.9955499,0.0003514949,0.0007294818,0.0009512635,0.001396998,0.001020927],"domain_scores_gemma":[0.9960199,0.001386389,0.0001157912,0.0007928841,0.000261912,0.00142313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003248615,0.0001550337,0.00345722,0.00009839072,0.000129715,0.0001275073,0.0001798849,0.00003386721,0.9794281,0.000176701,0.00091746,0.01497131],"study_design_scores_gemma":[0.001818366,0.0008496545,0.005332008,0.0002365782,0.0001515378,0.00001587356,0.0001128632,0.0004492983,0.9819068,0.00008272499,0.008629071,0.0004152025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912543,0.0004052329,0.0004644386,0.001424004,0.0006521835,0.0009176682,0.00002614108,0.000134598,0.004721428],"genre_scores_gemma":[0.9942988,0.00003558251,0.001452998,0.0007937803,0.001135601,0.00008088049,0.00003003385,0.00009895565,0.002073361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0145561,"threshold_uncertainty_score":0.999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151110654130702,"score_gpt":0.2865605144011594,"score_spread":0.2550494078598524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}