{"id":"W1551450716","doi":"10.1196/annals.1348.032","title":"Characterization of Antisense Oligonucleotides Comprising 2′‐Deoxy‐2′‐Fluoro‐β‐<scp>d</scp>‐Arabinonucleic Acid (FANA)","year":2006,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hôpital Notre-Dame; Xenon Pharmaceuticals (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oligonucleotide; Nuclease; Molecular biology; Gene knockdown; Gene silencing; DNA; Sense (electronics); RNA; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223824,0.0002637277,0.0001567912,0.0001180454,0.00009340147,0.000141645,0.00007208545,0.0002219935,0.0004744859],"category_scores_gemma":[0.0003572389,0.00009079729,0.0001309823,0.00006980091,0.0001477997,0.0001388405,0.00005178967,0.0001834963,0.0001829506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970649,"about_ca_system_score_gemma":0.000211871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006786499,"about_ca_topic_score_gemma":0.0007538943,"domain_scores_codex":[0.9999192,0.00001423215,0.000007293094,0.00002479095,0.00002466241,0.000009848763],"domain_scores_gemma":[0.9998294,0.00006061703,0.0000385595,0.000008905815,0.0000389577,0.00002339437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008342257,0.000002330052,0.00003901466,0.000007244306,7.815901e-7,0.000004632431,0.000004425637,0.00003282651,0.999552,0.00001471442,0.000002410738,0.0003312083],"study_design_scores_gemma":[0.000004342852,0.000209719,0.001282951,0.000002307347,0.000006750066,0.00009500396,0.000008159398,0.000567809,0.996738,0.00001781464,0.001064655,0.000002435961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807294,0.001097144,0.01678029,0.00004401399,0.00002061382,0.00006832869,0.0002683545,0.00005986838,0.0009320757],"genre_scores_gemma":[0.9782048,0.0009227333,0.01714396,0.00005693554,0.00000959121,0.0001188811,0.0008423556,0.0000340914,0.002666653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006786499,"threshold_uncertainty_score":0.001587331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03891891025129956,"score_gpt":0.2852733519580558,"score_spread":0.2463544417067562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}