{"id":"W1551450716","doi":"10.1196/annals.1348.032","title":"Characterization of Antisense Oligonucleotides Comprising 2′‐Deoxy‐2′‐Fluoro‐β‐<scp>d</scp>‐Arabinonucleic Acid (FANA)","year":2006,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hôpital Notre-Dame; Xenon Pharmaceuticals (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oligonucleotide; Nuclease; Molecular biology; Gene knockdown; Gene silencing; DNA; Sense (electronics); RNA; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003961496,0.0001464875,0.0002480192,0.0000915943,0.0001201658,0.00002065299,0.0007312965,0.0001479686,0.00000529531],"category_scores_gemma":[0.00008558307,0.0001105325,0.0001760024,0.0003589863,0.0006909977,0.00002518971,0.0001632083,0.00008754247,0.000003130259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002183976,"about_ca_system_score_gemma":0.00006547213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161307,"about_ca_topic_score_gemma":0.000004870761,"domain_scores_codex":[0.998632,0.00006655893,0.0004418411,0.0002878318,0.0003155289,0.0002562682],"domain_scores_gemma":[0.9991322,0.00003039455,0.0005512097,0.0001530638,0.0000843807,0.00004877217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001108252,0.00003801334,0.004136046,0.00002167725,0.0000214129,7.477083e-8,0.00007180368,0.0001447672,0.9878803,0.00023352,0.00591527,0.001526053],"study_design_scores_gemma":[0.0001075851,0.0001737524,0.05687493,0.0001048952,0.00001411544,0.000003880793,0.00009227535,0.00006765212,0.9384172,0.0006716318,0.003412147,0.00005994016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965898,0.001378994,0.00008947176,0.0009223668,0.00009572681,0.0001209759,0.00002472212,0.000006147775,0.0007718076],"genre_scores_gemma":[0.9980376,0.0005740075,0.0003293385,0.0004191032,0.0001597544,9.931208e-7,0.000007150454,0.000008739038,0.0004633105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05273888,"threshold_uncertainty_score":0.4507386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03891891025129956,"score_gpt":0.2852733519580558,"score_spread":0.2463544417067562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}