{"id":"W1551854884","doi":"10.1038/cddis.2015.151","title":"Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells","year":2015,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Krembil Foundation","keywords":"Neurogenesis; Microglia; Cell biology; Biology; Cell cycle; Apoptosis; Programmed cell death; Cell cycle checkpoint; Cancer research; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009436048,0.0003047282,0.0002640526,0.0001408813,0.0001213761,0.0001338876,0.0001867777,0.00006595023,0.00001728166],"category_scores_gemma":[0.0002982064,0.0002842611,0.00006378327,0.0002177832,0.000116084,0.0001851512,0.0001357516,0.0001597821,0.00006873268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000187774,"about_ca_system_score_gemma":0.0001083113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000181929,"about_ca_topic_score_gemma":0.00000233677,"domain_scores_codex":[0.9979733,0.0002162224,0.0002670443,0.0007747181,0.0002611176,0.0005075918],"domain_scores_gemma":[0.9978237,0.0002681414,0.00009574743,0.0002611794,0.00002658652,0.001524655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003801308,0.0003417634,0.001064986,0.0000803944,9.128329e-7,0.0002132657,0.0001367675,0.00006976717,0.997239,0.00001896185,0.0003002785,0.0001537748],"study_design_scores_gemma":[0.002160948,0.0001837273,0.001105815,0.00001279477,0.00004369471,0.00000376166,0.00005127635,0.00502014,0.9905838,0.00007961621,0.000434578,0.0003197846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978527,0.000425771,0.00001942644,0.00009460231,0.0004988159,0.0004211913,0.000186168,0.00007735074,0.0004240147],"genre_scores_gemma":[0.9979365,0.0004003287,0.00004174806,0.001259,0.00004954862,0.00003010325,0.000008247983,0.0000415422,0.0002329449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006655133,"threshold_uncertainty_score":0.999961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518712209777207,"score_gpt":0.226672120174418,"score_spread":0.2014849980766459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}