{"id":"W1551896540","doi":"10.3390/v7072790","title":"Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Elvitegravir; Raltegravir; Integrase; Integrase inhibitor; Drug resistance; Virology; Biology; Drug; Medicine; Pharmacology; Genetics; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002101026,0.000518228,0.001476272,0.0002406388,0.00007861826,0.00004138112,0.0001224134,0.0001995207,0.0000278599],"category_scores_gemma":[0.000156585,0.000362503,0.0002179766,0.0003748394,0.0001015287,0.00009453258,0.00003346748,0.0002954443,0.0002586567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474429,"about_ca_system_score_gemma":0.0004925332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003336127,"about_ca_topic_score_gemma":0.00006258082,"domain_scores_codex":[0.9981164,0.00007130006,0.0005183248,0.0006059314,0.0003700126,0.0003180183],"domain_scores_gemma":[0.9988898,0.0001551985,0.00006261784,0.0003684325,0.00009567986,0.0004282753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001570718,0.0001526397,0.00006963073,0.01043573,0.0004991158,0.0003814879,0.00101436,8.452196e-8,0.000007196171,0.00009171054,0.04302246,0.9441685],"study_design_scores_gemma":[0.00062896,0.0000538558,0.000002477949,0.02305469,0.0009643487,0.00001683867,0.0001232003,1.320848e-7,0.00003582616,0.00000540146,0.9747627,0.0003515448],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002950517,0.993715,0.00002020894,0.0003875245,0.0001387053,0.00116125,0.0001626558,0.0000802137,0.004039384],"genre_scores_gemma":[0.00004956817,0.9801952,0.00100429,0.000328622,0.0001404804,0.0001378225,0.00009433032,0.00006605865,0.01798358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.943817,"threshold_uncertainty_score":0.9998827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.078721512924904,"score_gpt":0.3304332009393257,"score_spread":0.2517116880144217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}