{"id":"W1551896540","doi":"10.3390/v7072790","title":"Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence","year":2015,"lang":"en","type":"review","venue":"Viruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Dolutegravir; Elvitegravir; Raltegravir; Integrase; Integrase inhibitor; Drug resistance; Virology; Biology; Drug; Medicine; Pharmacology; Genetics; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005106435,0.0005834954,0.001119949,0.001993439,0.0002514113,0.001021102,0.0006304402,0.001007084,0.003973128],"category_scores_gemma":[0.0008865661,0.0002347118,0.0004917647,0.001590839,0.0005908202,0.001151957,0.000592867,0.001571076,0.001618638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005346235,"about_ca_system_score_gemma":0.001002201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131646,"about_ca_topic_score_gemma":0.001754098,"domain_scores_codex":[0.9997942,0.00003911465,0.00003577933,0.00003363361,0.00007525158,0.00002207808],"domain_scores_gemma":[0.9996129,0.0002003746,0.00006622175,0.0000100801,0.00008654813,0.0000239773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006083638,0.00004820708,0.0002236779,0.02216835,0.00008173621,0.0003001917,0.0001103416,0.0002627877,0.001678148,0.005439301,0.02476517,0.9448612],"study_design_scores_gemma":[0.000009899407,0.00006210357,0.0007210983,0.00470607,0.00008061501,0.001957421,0.00008419737,0.00005831609,0.0004392004,0.002260367,0.9896063,0.00001434191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008348004,0.9988273,0.00004720168,0.0002072705,0.0001128924,0.000002122536,0.000008814378,0.00000318055,0.0007077411],"genre_scores_gemma":[0.0006601774,0.9985124,0.00008816732,0.0001815,0.0001056491,0.00000283627,0.00001502701,9.134551e-7,0.0004332928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003973128,"threshold_uncertainty_score":0.01329142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.078721512924904,"score_gpt":0.3304332009393257,"score_spread":0.2517116880144217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}