{"id":"W1552214555","doi":"10.18433/j3v30r","title":"Differential Effects of Chrysin on Nitrofurantoin Pharmacokinetics Mediated by Intestinal Breast Cancer Resistance Protein in Rats and Mice","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chrysin; Nitrofurantoin; Abcg2; Pharmacology; Ileum; Pharmacokinetics; Intraperitoneal injection; Chemistry; Jejunum; Small intestine; Duodenum; P-glycoprotein; Western blot; Endocrinology; Internal medicine; Flavonoid; Medicine; ATP-binding cassette transporter; Antibiotics; Multiple drug resistance; Transporter; Biochemistry; Antioxidant","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082434,0.0008038618,0.0006253672,0.001129954,0.0003100581,0.0003434023,0.0002525761,0.0005834978,0.001888029],"category_scores_gemma":[0.0002616751,0.0004452912,0.0006589558,0.000333589,0.0006697889,0.0006750459,0.0002206701,0.001496447,0.0004399086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007277869,"about_ca_system_score_gemma":0.0004405099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430629,"about_ca_topic_score_gemma":0.002135531,"domain_scores_codex":[0.9996485,0.00005903743,0.00001873903,0.00009023106,0.00007373981,0.0001098449],"domain_scores_gemma":[0.9995536,0.00005509833,0.0001496679,0.00006163463,0.00004081874,0.0001391421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004202499,0.0006241318,0.0007451107,0.00005010658,0.00002405174,0.00006754374,0.00005038662,0.0001113755,0.9914787,0.00009789597,0.00008919516,0.0024591],"study_design_scores_gemma":[0.0003482337,0.01138529,0.01171691,0.000008683409,0.0001394218,0.0002869364,0.0001196926,0.001287415,0.9726299,0.0001202795,0.001927666,0.00002966537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963856,0.0008034669,0.001404696,0.0001915714,0.00003588951,0.00004923789,0.0004714338,0.0001268172,0.0005313564],"genre_scores_gemma":[0.9907293,0.001224574,0.002490361,0.0001612478,0.00002731623,0.0001764332,0.000721392,0.00006554205,0.004403866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888029,"threshold_uncertainty_score":0.006316125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832972582053765,"score_gpt":0.3415174413861759,"score_spread":0.3231877155656382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}