{"id":"W1552317649","doi":"10.1111/bcp.12403","title":"The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future","year":2014,"lang":"en","type":"review","venue":"British Journal of Clinical Pharmacology","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"ViiV Healthcare; Gilead Sciences; Bristol-Myers Squibb","keywords":"Pharmacogenomics; Human immunodeficiency virus (HIV); Drug; Medicine; Intensive care medicine; Antiretroviral therapy; Pharmacology; Immunology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007709072,0.0001887313,0.002703836,0.0001046328,0.000120316,0.00001250636,0.0007896335,0.0003846557,0.00009187401],"category_scores_gemma":[0.002341472,0.00008675418,0.002330402,0.0002166562,0.002247151,0.00005659685,0.0001553408,0.002037943,0.00000100974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004082503,"about_ca_system_score_gemma":0.0009689539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003528871,"about_ca_topic_score_gemma":0.00005474091,"domain_scores_codex":[0.9926103,0.003333247,0.003079504,0.0001837666,0.0005394133,0.0002537463],"domain_scores_gemma":[0.9923266,0.003269841,0.003258773,0.0002727938,0.0007149221,0.0001571072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001279538,0.0004100064,0.0001553117,0.003356876,0.001421987,0.00001742942,0.00001975645,6.194646e-8,0.00001046523,0.0003942898,0.01824027,0.974694],"study_design_scores_gemma":[0.01107598,0.006222034,0.003575032,0.01210007,0.002349866,0.001638105,0.00008976884,0.00003109442,0.00001398537,0.0008893138,0.9619125,0.000102316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00352362,0.9916387,0.00002066021,0.002270136,0.0008634574,0.001114877,0.00004455547,0.00000255039,0.0005214994],"genre_scores_gemma":[0.01448898,0.9830731,0.00002926218,0.00005213,0.001990685,0.00001912314,0.000001879741,0.00002281862,0.000322082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9745917,"threshold_uncertainty_score":0.8853964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09616658305923957,"score_gpt":0.4670171726422771,"score_spread":0.3708505895830375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}