{"id":"W1552674655","doi":"10.1186/1471-213x-5-1","title":"Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: Effect of cofactors on differentiating lineages","year":2005,"lang":"en","type":"article","venue":"BMC Developmental Biology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Heritage Foundation for Medical Research; Bundesministerium für Bildung und Forschung","keywords":"Cell biology; Decorin; Biglycan; Biology; Embryonic stem cell; Stem cell; Cartilage; Bone morphogenetic protein 2; Osteoblast; Bone morphogenetic protein; Cellular differentiation; Adipogenesis; Proteoglycan; Extracellular matrix; Anatomy; Biochemistry; Mesenchymal stem cell; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001584976,0.0001897174,0.0004597164,0.0001672486,0.00002907287,0.000002730264,0.00004097775,0.0001555269,0.00003887977],"category_scores_gemma":[0.00001718213,0.0001505494,0.00004845918,0.0001215169,0.00006518026,0.00003735308,0.00004096061,0.00009145257,0.000008792197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008559308,"about_ca_system_score_gemma":0.00004890865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001454326,"about_ca_topic_score_gemma":0.00005437403,"domain_scores_codex":[0.9989477,0.0001302095,0.0003555731,0.0002658039,0.00009812581,0.000202548],"domain_scores_gemma":[0.9995865,0.00008838839,0.0001554839,0.00009024151,0.00001813887,0.00006130357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003425613,0.0001086751,0.08573467,0.0001255082,0.00002669106,0.000002046379,0.000105513,5.003899e-7,0.8632414,0.000008943136,0.000004058761,0.05029948],"study_design_scores_gemma":[0.003965552,0.003619251,0.01452177,0.0002241012,0.00004149376,0.00002485528,0.00009973123,0.000004174003,0.977325,0.000002531672,0.00005555266,0.0001159563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977863,0.001141359,0.00001045649,0.00001668596,0.00009672197,0.000859645,0.00002926719,0.00001530782,0.00004425885],"genre_scores_gemma":[0.9979041,0.00005916844,0.001572469,0.00001354956,0.00002157638,0.00006819345,0.00007553306,0.00001664991,0.000268731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1140837,"threshold_uncertainty_score":0.6139227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079735305527623,"score_gpt":0.231381011640038,"score_spread":0.2205836585847618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}