{"id":"W1552800067","doi":"10.1128/jvi.00845-15","title":"Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Biology; RIG-I; Virology; Virus; Innate immune system; TLR3; Influenza A virus; Viral replication; Chikungunya; Dengue virus; Interferon; Viral pathogenesis; TLR7; Antiviral drug; RNA virus; RNA; Immune system; Immunology; Toll-like receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001288275,0.0001917344,0.0003846917,0.0001797115,0.0002159025,0.00002967309,0.0006149546,0.0002809852,0.0002286743],"category_scores_gemma":[0.0003817053,0.0001265869,0.0001524109,0.0001850825,0.0006822462,0.0001807346,0.00007138401,0.0008328108,0.0005021994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307069,"about_ca_system_score_gemma":0.0002702637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002303347,"about_ca_topic_score_gemma":0.000003996282,"domain_scores_codex":[0.9969635,0.00177749,0.0005950287,0.0001898359,0.00007246678,0.0004016766],"domain_scores_gemma":[0.9983349,0.0005319556,0.0005136856,0.0003781256,0.0001986871,0.00004261162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01037011,0.0001554486,0.00004140107,9.736441e-7,0.0001368409,0.0000207074,0.0006184283,0.00001039754,0.9094854,0.0003026312,0.07801733,0.000840306],"study_design_scores_gemma":[0.0009879778,0.00120064,0.001296157,0.00001056635,0.0000211019,0.0008850034,0.0002970294,0.000004664359,0.6359941,0.0002595261,0.3589347,0.0001085139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798002,0.006158032,0.000548938,0.01131675,0.001311292,0.0001188147,0.00003110804,0.00002412901,0.000690746],"genre_scores_gemma":[0.9942061,0.0004299959,0.00003718812,0.0004823506,0.00006484248,0.000005853186,0.00001146609,0.0000176401,0.004744542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2809173,"threshold_uncertainty_score":0.6454924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03478158910855544,"score_gpt":0.2966489330573345,"score_spread":0.2618673439487791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}