{"id":"W1552867725","doi":"10.1002/cncr.28744","title":"Dual blockade of epidermal growth factor receptor and insulin‐like growth factor receptor–1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)","year":2014,"lang":"en","type":"article","venue":"Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute","keywords":"Medicine; Erlotinib; Gemcitabine; Internal medicine; Epidermal growth factor receptor; Oncology; Phases of clinical research; Progression-free survival; Neutropenia; Pharmacology; Gastroenterology; Cancer; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001658388,0.0006041556,0.003733924,0.0005164933,0.0001755272,0.00002783198,0.0001671262,0.0002813445,0.0009202395],"category_scores_gemma":[0.004039716,0.0004883449,0.0002123435,0.0004979546,0.001188922,0.0002429921,0.0001684488,0.0005949672,0.000002137429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002711293,"about_ca_system_score_gemma":0.0009142089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297496,"about_ca_topic_score_gemma":0.0001731803,"domain_scores_codex":[0.9950292,0.0009650128,0.00170086,0.0008239227,0.0006943838,0.0007866978],"domain_scores_gemma":[0.9939388,0.003887781,0.0007747019,0.0003579886,0.0004675044,0.0005732306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9053528,0.001914535,0.01026886,0.002356382,0.002031448,0.00002927206,0.006558924,0.000006113824,0.05299217,0.0002987588,0.0003752252,0.01781546],"study_design_scores_gemma":[0.9706247,0.008115685,0.001622573,0.0008235927,0.001857803,0.00001714192,0.0005399707,0.003730909,0.01169122,0.0001291702,0.0003175201,0.0005297391],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857054,0.008019208,0.0001752807,0.000879141,0.0006156089,0.003780578,0.000646352,0.00004422194,0.0001342367],"genre_scores_gemma":[0.9869717,0.009438045,0.001840318,0.0001082636,0.0005411499,0.0006981987,0.00008603624,0.00007816742,0.0002380801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06527183,"threshold_uncertainty_score":0.999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04866528388977199,"score_gpt":0.3657734810663791,"score_spread":0.3171081971766072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}