{"id":"W1552867725","doi":"10.1002/cncr.28744","title":"Dual blockade of epidermal growth factor receptor and insulin‐like growth factor receptor–1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)","year":2014,"lang":"en","type":"article","venue":"Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute","keywords":"Medicine; Erlotinib; Gemcitabine; Internal medicine; Epidermal growth factor receptor; Oncology; Phases of clinical research; Progression-free survival; Neutropenia; Pharmacology; Gastroenterology; Cancer; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002083589,0.001863477,0.002154737,0.0005275081,0.0003166886,0.001091997,0.000994357,0.0009437653,0.003745863],"category_scores_gemma":[0.0008441588,0.0006453284,0.001156571,0.0005175669,0.001174172,0.0008982042,0.0003695872,0.003806421,0.0007163092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118486,"about_ca_system_score_gemma":0.001657031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008295964,"about_ca_topic_score_gemma":0.002062052,"domain_scores_codex":[0.9995401,0.0002409765,0.00002601529,0.0000728943,0.00004343793,0.00007657966],"domain_scores_gemma":[0.9993328,0.0001163089,0.0001556637,0.00003953679,0.00003124473,0.0003243444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9177888,0.02247963,0.002784956,0.0006550351,0.0009321123,0.00007392849,0.00008683484,0.001311224,0.01497255,0.0001625302,0.001561158,0.03719125],"study_design_scores_gemma":[0.8081422,0.1824981,0.003920786,0.00003273988,0.0004504736,0.0001334525,0.00003201625,0.001006523,0.002838266,0.0001010535,0.0008280841,0.00001630027],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994352,0.002046375,0.0002316866,0.0003652046,0.0001204357,0.001304747,0.0003630229,0.0000695191,0.001147131],"genre_scores_gemma":[0.9934168,0.001480646,0.0009680877,0.0004474062,0.0002051442,0.001381541,0.0008111955,0.00001874188,0.001270487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003745863,"threshold_uncertainty_score":0.0125311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04866528388977199,"score_gpt":0.3657734810663791,"score_spread":0.3171081971766072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}