{"id":"W1553161684","doi":"10.4049/jimmunol.192.supp.113.7","title":"Human peripheral invariant natural killer T are adaptive lymphocytes, whose TCR CDR3β regulates their antigen specificity and reactivity to avoid harmful autoimmune responses (BA8P.124)","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"CD1D; T-cell receptor; Biology; Immunology; Natural killer T cell; Acquired immune system; Antigen; Adoptive cell transfer; Cell biology; Autoimmunity; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000739851,0.0001820877,0.0001058203,0.0001117521,0.00009416752,0.0002010644,0.00007744367,0.0001222123,0.001719055],"category_scores_gemma":[0.0001068037,0.00004636665,0.0001242771,0.00008296815,0.0001157974,0.00007064998,0.0001385352,0.0002484602,0.0005860187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000084435,"about_ca_system_score_gemma":0.0001067018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729191,"about_ca_topic_score_gemma":0.000181346,"domain_scores_codex":[0.9999146,0.00001184762,0.000007224915,0.00002433827,0.00001884925,0.00002300156],"domain_scores_gemma":[0.9999564,0.000007757287,0.00001027528,0.000006958057,0.000006817017,0.00001183461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062066,0.00001753159,0.001683905,0.00001924789,0.000003367848,0.00007061453,0.0000101157,0.0000472887,0.9926947,0.00004777394,0.00004897762,0.00525036],"study_design_scores_gemma":[0.00003250752,0.0006431598,0.02407677,0.00001011731,0.0000312296,0.001996027,0.00003674697,0.0007807115,0.9671462,0.0002017045,0.005038886,0.000006023434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934787,0.0009927307,0.003196592,0.00003545692,0.00001822076,0.00002061784,0.0001806156,0.00008284074,0.001994326],"genre_scores_gemma":[0.9972264,0.0002198349,0.001087546,0.00003401444,0.000006583959,0.00000934134,0.0002442211,0.000008580241,0.001163449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719055,"threshold_uncertainty_score":0.005750835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578983702229276,"score_gpt":0.2306788985509012,"score_spread":0.2148890615286085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}