{"id":"W1553190261","doi":"10.1073/pnas.242321099","title":"RAG-dependent peripheral T cell receptor diversification in CD8 <sup>+</sup> T lymphocytes","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Canadian Diabetes Association","keywords":"T-cell receptor; Biology; Recombination-activating gene; CD8; Cytotoxic T cell; T cell; Molecular biology; NOD mice; Lymphocytic choriomeningitis; Cell biology; Antigen; Immune system; Immunology; Gene; Autoimmunity; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008512104,0.0001639843,0.0001164976,0.0001658317,0.0001066815,0.0003309352,0.0001208091,0.0001552989,0.001246152],"category_scores_gemma":[0.00009504532,0.0001271429,0.0001011359,0.00008588337,0.0001964945,0.0001246688,0.0001631002,0.0003973258,0.000709547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267275,"about_ca_system_score_gemma":0.00008206444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335804,"about_ca_topic_score_gemma":0.0001870242,"domain_scores_codex":[0.9999044,0.00001563623,0.00000752612,0.00002685683,0.00001561989,0.00002998955],"domain_scores_gemma":[0.9999115,0.00000971247,0.00002405125,0.00001498764,0.000009771532,0.00002984223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009014024,0.00001124329,0.0006483023,0.00001191504,0.000001327606,0.00006658368,0.00001270691,0.00002878762,0.9974248,0.00007901897,0.00002331397,0.001601943],"study_design_scores_gemma":[0.0001136084,0.0009140558,0.03631515,0.00002006033,0.00003240229,0.005849524,0.00009915015,0.001706809,0.9494925,0.0004634591,0.004981089,0.00001219611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969398,0.0004907511,0.001036842,0.00003213215,0.000005549924,0.00001071533,0.00009977633,0.000072886,0.001311621],"genre_scores_gemma":[0.9972745,0.0001985315,0.0006531723,0.0000264871,0.000009659155,0.00001397101,0.0002502365,0.00001639174,0.001557189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246152,"threshold_uncertainty_score":0.004168808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050950733752259,"score_gpt":0.2485120763099152,"score_spread":0.2180025689723926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}