{"id":"W1553448703","doi":"10.1096/fasebj.28.1_supplement.258.1","title":"Ketoisocaproic acid suppresses insulin‐stimulated glucose transport in parallel with activation of mTORC1 in muscle cells (258.1)","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Leucine; Valine; IRS1; mTORC1; Internal medicine; Amino acid; P70-S6 Kinase 1; Endocrinology; Isoleucine; Insulin; Arginine; Insulin resistance; Phosphorylation; Biochemistry; Biology; Chemistry; Insulin receptor; Medicine; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002371437,0.000724311,0.0006404659,0.0004165667,0.0002282164,0.0004944915,0.0003291439,0.00034482,0.001962247],"category_scores_gemma":[0.0001500393,0.0002757128,0.0004580729,0.0002992387,0.0003532133,0.0002946983,0.0002526471,0.0007440694,0.0005692803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004538688,"about_ca_system_score_gemma":0.000383031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492833,"about_ca_topic_score_gemma":0.002785844,"domain_scores_codex":[0.9996819,0.00006588358,0.00005661981,0.00006105724,0.00008047053,0.00005412396],"domain_scores_gemma":[0.9997767,0.00002912211,0.00006439093,0.00002563577,0.00002892007,0.000075224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001106195,0.00009461334,0.0001696781,0.00009507518,0.00001593716,0.00004579681,0.00001311571,0.00002971816,0.9973626,0.00004865607,0.0001061416,0.0009125672],"study_design_scores_gemma":[0.00008936958,0.001782982,0.00785489,0.00001141484,0.00003366174,0.0001922916,0.00004702826,0.0005066827,0.986596,0.00002688456,0.002852535,0.000006130655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871516,0.006317893,0.001655289,0.0002713288,0.0001990963,0.00005763673,0.00124051,0.000221663,0.00288501],"genre_scores_gemma":[0.9869348,0.003319365,0.002739017,0.0001884682,0.00008299235,0.0001156823,0.001356836,0.0000547081,0.005208243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962247,"threshold_uncertainty_score":0.006564379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00748370583747853,"score_gpt":0.2103430941027412,"score_spread":0.2028593882652627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}