{"id":"W1553860208","doi":"10.1080/15476286.2015.1017204","title":"Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs","year":2015,"lang":"en","type":"article","venue":"RNA Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Dicer; Argonaute; Biology; RNA interference; Gene knockdown; Effector; Ribonuclease III; Small hairpin RNA; microRNA; Drosha; Gene silencing; Cell biology; Small interfering RNA; RNA; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768837,0.0001349225,0.0001529645,0.00004388249,0.00004886847,0.000009788278,0.0002912286,0.0001876516,0.00002168258],"category_scores_gemma":[0.0002064384,0.00008457682,0.00005767649,0.0000752635,0.0001083066,0.000002253866,0.0001052158,0.0001027753,0.00006001411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001316978,"about_ca_system_score_gemma":0.0001246324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004614963,"about_ca_topic_score_gemma":0.00005021742,"domain_scores_codex":[0.9991403,0.0001052606,0.0002047158,0.0002626591,0.00009590334,0.0001911171],"domain_scores_gemma":[0.9993311,0.00002830438,0.0001300109,0.0002799449,0.0001589323,0.0000717099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001488826,0.00006503442,0.00030469,0.000007728911,0.00004852572,0.000003851207,0.0001394926,0.00001355198,0.9928429,0.001577802,0.001205096,0.00364245],"study_design_scores_gemma":[0.0007595542,0.002244287,0.0006176578,0.00004045824,0.00003131869,0.00001713319,0.000506058,0.0003085377,0.9714211,0.004717636,0.01905879,0.0002774165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932005,0.0008908954,0.0008114408,0.0003106213,0.0002555303,0.0001275657,0.00001572295,0.00001030464,0.004377409],"genre_scores_gemma":[0.998672,0.0001084223,0.00004141964,0.0006279682,0.0001648732,0.00001618166,0.00009058027,0.00001138954,0.0002671649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02142175,"threshold_uncertainty_score":0.3448942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03394308560963959,"score_gpt":0.2685167942538348,"score_spread":0.2345737086441952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}