{"id":"W1553860208","doi":"10.1080/15476286.2015.1017204","title":"Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs","year":2015,"lang":"en","type":"article","venue":"RNA Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Dicer; Argonaute; Biology; RNA interference; Gene knockdown; Effector; Ribonuclease III; Small hairpin RNA; microRNA; Drosha; Gene silencing; Cell biology; Small interfering RNA; RNA; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004599383,0.0005541317,0.0002621176,0.0001541889,0.0002366502,0.0004622245,0.0003355056,0.0006232859,0.000995046],"category_scores_gemma":[0.0001987758,0.0002478231,0.0004614717,0.00005858768,0.0003590747,0.0006124323,0.000295084,0.0009080587,0.000482821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678036,"about_ca_system_score_gemma":0.0002372025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506182,"about_ca_topic_score_gemma":0.0001595141,"domain_scores_codex":[0.9998047,0.00003738805,0.00001834257,0.00004535246,0.00005576267,0.00003842734],"domain_scores_gemma":[0.9998766,0.00003344322,0.00003389902,0.00001568107,0.0000165998,0.00002388142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200128,0.000036994,0.0002463933,0.0001289964,0.00001044759,0.0003518311,0.000037902,0.0005428911,0.995077,0.002022544,0.00004841068,0.00137659],"study_design_scores_gemma":[0.00002017809,0.0002284227,0.00156732,0.00001051828,0.00001677724,0.0007235137,0.00003719702,0.005658535,0.9878559,0.001104594,0.002761411,0.00001586291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539105,0.005970239,0.02939693,0.0005342388,0.0000865585,0.0001088338,0.0002756916,0.0002127868,0.009504293],"genre_scores_gemma":[0.989292,0.001692321,0.007178767,0.000214828,0.00002078493,0.00003744829,0.0001710817,0.00002022408,0.001372637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000995046,"threshold_uncertainty_score":0.003328741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03394308560963959,"score_gpt":0.2685167942538348,"score_spread":0.2345737086441952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}