{"id":"W1553960197","doi":"10.1139/o06-186","title":"ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate–partner associationsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.","year":2006,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Calnexin; Protein disulfide-isomerase; Endoplasmic reticulum; Calreticulin; Foldase; Isomerase; Protein folding; Oxidative folding; Biochemistry; Endoplasmic-reticulum-associated protein degradation; Chaperone (clinical); Chemistry; Unfolded protein response; Cell biology; Biology; Enzyme; GroEL","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001362864,0.0003509624,0.0008059506,0.0001044713,0.00006554082,0.00002562776,0.0000861936,0.0003608881,0.000535207],"category_scores_gemma":[0.00009261071,0.0002833294,0.000105009,0.0001468119,0.0003373881,0.000006216545,0.00007138614,0.0002080241,1.269657e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658691,"about_ca_system_score_gemma":0.0003971016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159243,"about_ca_topic_score_gemma":0.00009751123,"domain_scores_codex":[0.9981966,0.0001651022,0.0006073249,0.0006392161,0.0001165176,0.0002752569],"domain_scores_gemma":[0.999108,0.00004387809,0.0004441629,0.0001842554,0.00003597258,0.000183745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002883313,0.002701651,0.06317821,0.0800391,0.0007698696,0.00003221583,0.0002949867,0.0000267977,0.8026716,0.0001162857,0.001024339,0.04626163],"study_design_scores_gemma":[0.009927234,0.001941325,0.006648773,0.01156052,0.0006913077,0.00005949007,0.0003799587,0.00004069274,0.5087857,0.0004935474,0.4566838,0.00278761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5608112,0.4368722,0.000004960501,0.0001034672,0.00002568347,0.00088236,0.0004962845,0.000006137681,0.0007976568],"genre_scores_gemma":[0.3005319,0.6933429,0.0006083571,0.0001027747,0.0006634375,0.0004760987,0.002165793,0.00006222016,0.002046559],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.4556594,"threshold_uncertainty_score":0.9999619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007182186617882835,"score_gpt":0.2376421197871176,"score_spread":0.2304599331692347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}