{"id":"W1554495658","doi":"","title":"AR47A6.4.2, a naked monoclonal antibody targeting Trop-2, exhibits anti-tumor efficacy in multiple human cancer models as a monotherapeutic agent and demonstrates efficacy in combination therapy","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arius3D (Canada)","funders":"","keywords":"Pancreatic cancer; Cancer; Gemcitabine; In vivo; Colorectal cancer; Medicine; Monoclonal antibody; Cancer research; Antibody; Metastasis; Prostate cancer; Breast cancer; Growth inhibition; Combination therapy; Internal medicine; Oncology; Immunology; Apoptosis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603844,0.0004179679,0.000509788,0.0005165595,0.000107645,0.0002440859,0.00025618,0.000347557,0.001633202],"category_scores_gemma":[0.00006713077,0.0001743802,0.0004174592,0.0002699225,0.0001217673,0.0001811787,0.000156172,0.0007449271,0.0005355043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202854,"about_ca_system_score_gemma":0.000174671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005038057,"about_ca_topic_score_gemma":0.0009359113,"domain_scores_codex":[0.9998733,0.0000178437,0.000007447761,0.00002042562,0.00004796359,0.00003317478],"domain_scores_gemma":[0.9999548,0.000005673795,0.00001149369,0.000006330953,0.000007098395,0.00001460707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005241086,0.0004503447,0.0002575644,0.0001404309,0.00003609235,0.00008693002,0.00001390903,0.0003294071,0.9798614,0.0001190771,0.0006266917,0.01755412],"study_design_scores_gemma":[0.0002339807,0.007206419,0.005104425,0.00001488849,0.0001119121,0.0009415508,0.00001648822,0.00270051,0.9681095,0.00005612779,0.01548676,0.0000174464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714023,0.0141249,0.00417315,0.0002457478,0.0001604308,0.000112666,0.0006102805,0.0004733823,0.008697025],"genre_scores_gemma":[0.9798718,0.006251849,0.003767395,0.0001167762,0.00003597534,0.0001154422,0.001408792,0.00003991057,0.008392112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633202,"threshold_uncertainty_score":0.0054636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07728802983399234,"score_gpt":0.3903754138534551,"score_spread":0.3130873840194627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}