{"id":"W1554800282","doi":"10.1186/s12974-015-0309-5","title":"CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"Ccaat-enhancer-binding proteins; Inflammation; Meningitis; Streptococcus pneumoniae; Immunology; Spleen; Medicine; Sepsis; Biology; Transcription factor; Internal medicine; Microbiology; DNA-binding protein; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003896241,0.0001437781,0.0002298452,0.000258488,0.0001551838,0.00009916002,0.00007930691,0.0001328319,0.0000805427],"category_scores_gemma":[0.0003700252,0.0001280544,0.00005736111,0.0001318799,0.00003837141,0.0008480387,0.00004041452,0.0002088424,0.00002823614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006693271,"about_ca_system_score_gemma":0.00004453935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007605669,"about_ca_topic_score_gemma":0.000008190645,"domain_scores_codex":[0.9988963,0.0001620804,0.0005952161,0.0001303622,0.00004906645,0.0001669561],"domain_scores_gemma":[0.998821,0.00005662346,0.000688713,0.00009049803,0.0002974126,0.0000457202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003467276,0.00002081694,0.00004696225,0.00002668274,0.00003207972,0.000004491807,0.0004444285,0.000008885022,0.9950344,0.00008301414,0.00006610595,0.003885402],"study_design_scores_gemma":[0.001251418,0.0003125698,0.001801241,0.0001476045,0.00003419566,0.0005897313,0.000120116,0.00001439524,0.9945772,0.0001311144,0.0008986475,0.0001217157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981427,0.00007239627,0.00002007409,0.0003109235,0.001114861,0.0002203073,0.000004343581,0.00003309028,0.00008129437],"genre_scores_gemma":[0.9990212,0.00003874418,0.0001076638,1.882335e-8,0.0004372009,0.000008484541,0.00003373759,0.00001526969,0.0003377032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003763686,"threshold_uncertainty_score":0.5221908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377871505005077,"score_gpt":0.2482522323722155,"score_spread":0.2344735173221648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}