{"id":"W1554834260","doi":"10.1074/jbc.m115.636712","title":"Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Guanine nucleotide exchange factor; Proto-Oncogene Proteins c-akt; Protein kinase B; Cell biology; Pleckstrin homology domain; GTPase; Chemistry; Function (biology); Endosome; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004636908,0.0001755747,0.00008767155,0.00007305358,0.00010439,0.0001725362,0.00008158146,0.00008708072,0.001100198],"category_scores_gemma":[0.00006571483,0.00008163095,0.0001104325,0.00006344718,0.0001388837,0.0001164951,0.0001529571,0.0002087324,0.0002374536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428966,"about_ca_system_score_gemma":0.00006824998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003938533,"about_ca_topic_score_gemma":0.0008283605,"domain_scores_codex":[0.9999551,0.000006626366,0.00000373076,0.00001397491,0.00001006354,0.00001068905],"domain_scores_gemma":[0.9999648,0.000007175062,0.00001010796,0.000003771808,0.000003549479,0.000010454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007343946,0.000009897862,0.0002503507,0.00001200582,0.000001941252,0.00003405589,0.000004990841,0.00004398225,0.9989826,0.00006356983,0.00002101447,0.0005021178],"study_design_scores_gemma":[0.00001014296,0.00003749891,0.01750481,0.000002438813,0.000005592134,0.000197909,0.00001686294,0.001177957,0.9797561,0.000045318,0.001241622,0.000003727111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981586,0.0003759626,0.0005452523,0.00002846026,0.000006911124,0.000003772601,0.0001417603,0.00002053575,0.0007186946],"genre_scores_gemma":[0.997503,0.0003620426,0.0006151936,0.00002619341,0.00000202514,0.000006146154,0.0003518802,0.000007499072,0.001126002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100198,"threshold_uncertainty_score":0.003680587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03037934109720244,"score_gpt":0.2403476296252154,"score_spread":0.209968288528013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}