{"id":"W1555288604","doi":"10.1111/bph.12346","title":"Chronic inhibition of cGMP‐specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure","year":2013,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Endoplasmic reticulum; Heart failure; Phosphodiesterase; cGMP-specific phosphodiesterase type 5; Internal medicine; Medicine; Endocrinology; Phosphodiesterase 3; Cell biology; Pharmacology; Chemistry; Biology; Enzyme; Biochemistry; Sildenafil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406532,0.0003805894,0.0005804946,0.0001639686,0.0001765296,0.0002519061,0.000269595,0.000305718,0.0009519954],"category_scores_gemma":[0.0001495659,0.0001326738,0.0003279677,0.0001182124,0.0003150399,0.0002447424,0.0002078211,0.0009376575,0.0001862281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135676,"about_ca_system_score_gemma":0.0003386159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004669736,"about_ca_topic_score_gemma":0.001252297,"domain_scores_codex":[0.9999241,0.000009732453,0.0000100182,0.00001268221,0.00001190538,0.0000315948],"domain_scores_gemma":[0.9998889,0.00001281924,0.00003236584,0.00001159099,0.000009932431,0.00004435947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005822313,0.001315631,0.001486504,0.0003230566,0.00007287308,0.00008370868,0.00005323106,0.0002471444,0.9740049,0.0001430701,0.0004327593,0.01601477],"study_design_scores_gemma":[0.004113474,0.04271923,0.1039543,0.0001421886,0.0006597659,0.0005814313,0.0002936579,0.005953239,0.827646,0.0003240361,0.01357364,0.00003906544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892936,0.007604971,0.001623624,0.0002008535,0.0001357245,0.00005391452,0.0002003618,0.00007914822,0.0008078957],"genre_scores_gemma":[0.9949297,0.002399737,0.001047024,0.0001295496,0.00007805955,0.0000710426,0.0003593355,0.000009207559,0.0009762537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009519954,"threshold_uncertainty_score":0.003184795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005450277831469019,"score_gpt":0.2331975092458346,"score_spread":0.2277472314143656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}