{"id":"W1555378511","doi":"10.3389/fgene.2015.00230","title":"DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women","year":2015,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau québécois de recherche sur le vieillissement","keywords":"Oxytocin receptor; Oxytocin; Single-nucleotide polymorphism; Gene; DNA methylation; Anxiety; Genetics; Brain-derived neurotrophic factor; Psychology; Neurotrophic factors; Depression (economics); Epigenetics; Tropomyosin receptor kinase B; Biology; Receptor; Neuroscience; Psychiatry; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004738487,0.0002025528,0.0002308726,0.0001277522,0.00004602809,0.00005419798,0.000137387,0.0002255909,0.000001956358],"category_scores_gemma":[0.0002220259,0.0001674884,0.00001816081,0.0002340826,0.00008853886,0.00001160168,0.0000814313,0.0001528495,2.637109e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006777827,"about_ca_system_score_gemma":0.00005013584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001667584,"about_ca_topic_score_gemma":0.0001670042,"domain_scores_codex":[0.9983909,0.0003907645,0.0002827121,0.0004272214,0.0001985383,0.0003098775],"domain_scores_gemma":[0.9994004,0.00003476048,0.0001585516,0.0002465351,0.00006566487,0.00009410701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001129973,0.0001041797,0.6308832,0.00001221527,0.00001598503,0.00000422093,0.001535393,0.0005139366,0.3603342,4.762574e-7,0.0001583506,0.006324831],"study_design_scores_gemma":[0.002324661,0.0003831047,0.9387773,0.000054509,0.000009924778,0.000001660876,0.001160314,0.001293312,0.05417707,0.0002308943,0.001297473,0.0002897501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992452,0.005512562,0.00111769,0.0002003821,0.000178332,0.000464165,0.00001857534,0.000006264656,0.00005007809],"genre_scores_gemma":[0.9960635,0.001537967,0.001988136,0.0001842385,0.00006649289,0.00003921213,0.00005645253,0.00003256622,0.0000313981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3078941,"threshold_uncertainty_score":0.6829979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599158364524656,"score_gpt":0.2296823473580001,"score_spread":0.2136907637127535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}