{"id":"W1556338454","doi":"10.1111/j.1365-2826.2011.02167.x","title":"Caprospinol: Discovery of a Steroid Drug Candidate to Treat Alzheimer’s Disease Based on 22<i>R</i>‐Hydroxycholesterol Structure and Properties","year":2011,"lang":"en","type":"review","venue":"Journal of Neuroendocrinology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Drug; Steroid; Drug discovery; Internal medicine; Disease; Alzheimer's disease; Endocrinology; Drug candidate; Medicine; Pharmacology; Bioinformatics; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009615145,0.0004940234,0.0003043909,0.0005784806,0.0001581371,0.0002674953,0.000302117,0.0003757637,0.001999942],"category_scores_gemma":[0.0000780269,0.0001021784,0.0002451588,0.0003029364,0.0001794896,0.0002515487,0.0001940049,0.0003646337,0.0006074408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212904,"about_ca_system_score_gemma":0.0002259392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000669807,"about_ca_topic_score_gemma":0.001422034,"domain_scores_codex":[0.9999616,0.000005434961,0.000003099105,0.000008716343,0.00001197845,0.00000918472],"domain_scores_gemma":[0.9999652,0.000002091782,0.00000550631,0.000001950791,0.00001001554,0.00001525494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006201862,0.0002241289,0.0005717239,0.0005560829,0.00004162254,0.00117339,0.00007404489,0.0005609858,0.8876268,0.001687578,0.001129209,0.1057344],"study_design_scores_gemma":[0.0007510635,0.01285897,0.01467583,0.000163727,0.0002768833,0.005159384,0.0001000342,0.002758614,0.8079325,0.001292366,0.1539391,0.00009149931],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.85415,0.0942027,0.01635277,0.001124472,0.0003852829,0.0009206099,0.002765496,0.0005664896,0.02953224],"genre_scores_gemma":[0.9244965,0.04721763,0.01065498,0.0009144871,0.0002164785,0.0001503796,0.002879817,0.00003588193,0.01343386],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001999942,"threshold_uncertainty_score":0.006690502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04826181232437302,"score_gpt":0.3020434966096845,"score_spread":0.2537816842853116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}