{"id":"W1556447710","doi":"10.1002/path.4135","title":"Cancer‐associated somatic <i><scp>DICER1</scp></i> hotspot mutations cause defective <scp>miRNA</scp> processing and reverse‐strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage","year":2012,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"BC Cancer Agency; Canadian Institutes of Health Research","keywords":"Ribonuclease III; microRNA; Biology; RNase H; Somatic cell; Mutant; Molecular biology; RNase P; Gene; Messenger RNA; Genetics; RNA; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008280355,0.0002388769,0.0004014453,0.00008888928,0.0001794172,0.00002411891,0.0002163356,0.0003038676,0.000007538694],"category_scores_gemma":[0.0007393596,0.0001761922,0.0001234155,0.0001942795,0.0002361679,0.00005650759,0.00006928894,0.0002761242,0.000001265691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004393842,"about_ca_system_score_gemma":0.0001675629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001049752,"about_ca_topic_score_gemma":0.00003348389,"domain_scores_codex":[0.9981109,0.0005218832,0.0005537868,0.0001953976,0.0002357574,0.0003822484],"domain_scores_gemma":[0.9981198,0.0002641703,0.0009354422,0.000224221,0.0002926698,0.0001637355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182455,0.0001782921,0.009118786,0.0001471581,0.0001552357,0.00002792243,0.006824281,0.0003448451,0.9797556,0.000003795268,0.003079753,0.0002460678],"study_design_scores_gemma":[0.00292239,0.0006268132,0.1753248,0.0006102446,0.0007802245,0.0009858725,0.003350761,0.00002183958,0.8142005,0.0003560352,0.0007068392,0.0001136625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922023,0.005059833,0.001724007,0.00006592169,0.0001546479,0.0003581205,0.0002896096,0.000007464247,0.0001380992],"genre_scores_gemma":[0.9981123,0.0006203196,0.0007840946,0.00009445581,0.0002062324,0.00001236508,0.0000469331,0.00003470375,0.00008863785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.166206,"threshold_uncertainty_score":0.7184911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806512839461339,"score_gpt":0.2824973557085821,"score_spread":0.2644322273139688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}