{"id":"W1556447710","doi":"10.1002/path.4135","title":"Cancer‐associated somatic <i><scp>DICER1</scp></i> hotspot mutations cause defective <scp>miRNA</scp> processing and reverse‐strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage","year":2012,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"BC Cancer Agency; Canadian Institutes of Health Research","keywords":"Ribonuclease III; microRNA; Biology; RNase H; Somatic cell; Mutant; Molecular biology; RNase P; Gene; Messenger RNA; Genetics; RNA; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008283985,0.0004013423,0.0002450212,0.0002787027,0.0001370347,0.0002092024,0.0001640845,0.0002701083,0.001001167],"category_scores_gemma":[0.0001435114,0.0001508413,0.0002629082,0.0001914466,0.0002685937,0.0000974437,0.0001847254,0.0003065823,0.000334652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116865,"about_ca_system_score_gemma":0.0001376507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005298798,"about_ca_topic_score_gemma":0.0007525054,"domain_scores_codex":[0.9998977,0.000009232485,0.00001443066,0.00003030312,0.00003318951,0.00001516877],"domain_scores_gemma":[0.9997919,0.00003142533,0.0000944908,0.00003051194,0.00001799245,0.00003368736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003979596,0.000007827439,0.001488525,0.00002754168,0.000008421443,0.0003295426,0.00001127435,0.00007999024,0.9966814,0.00005542644,0.0000398102,0.001230465],"study_design_scores_gemma":[0.000007487985,0.0001121975,0.02303324,0.000003096826,0.00002622997,0.00507977,0.0000189068,0.0005777968,0.9692029,0.00005950189,0.001871141,0.000007710201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956191,0.0003953636,0.002378999,0.00003903446,0.00001398154,0.00002839333,0.0005272286,0.0001319617,0.0008659398],"genre_scores_gemma":[0.9964187,0.0002957543,0.001575468,0.00004276646,0.000004860722,0.00001423776,0.0005654266,0.00003114907,0.001051596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001167,"threshold_uncertainty_score":0.003349304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806512839461339,"score_gpt":0.2824973557085821,"score_spread":0.2644322273139688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}