{"id":"W1556784368","doi":"10.1186/1471-2164-7-73","title":"A high-throughput screen identifying sequence and promiscuity characteristics of the loxP spacer region in Cre-mediated recombination","year":2006,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency; Michael Smith Health Research BC","keywords":"Cre recombinase; Biology; Genetics; Cre-Lox recombination; Insert (composites); FLP-FRT recombination; Recombination; Site-specific recombination; Recombinase; Inverted repeat; DNA; Homologous recombination; Genome; Genetic recombination; Gene; Transgene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433402,0.0001102328,0.0001432453,0.00003717739,0.0000423733,0.00002051028,0.000145282,0.000245082,0.000001707789],"category_scores_gemma":[0.00006105687,0.00009356553,0.00003619069,0.00009595646,0.0001305652,0.000003363871,0.0001857056,0.00008762561,9.928605e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003003927,"about_ca_system_score_gemma":0.00006914821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877134,"about_ca_topic_score_gemma":0.001132131,"domain_scores_codex":[0.9992198,0.00005322182,0.0002608911,0.0002531347,0.00005720137,0.0001556953],"domain_scores_gemma":[0.9994464,0.000007582668,0.0001932323,0.0002796269,0.00005478619,0.00001837292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004458435,0.00003845442,0.02879729,0.00002723754,0.000006153258,8.204495e-7,0.00001858753,0.00001423456,0.969868,0.0002940976,0.0000707838,0.000819742],"study_design_scores_gemma":[0.0008163447,0.0001204944,0.4668859,0.00002529385,0.00001867654,0.00001711131,0.00003025714,0.0001958137,0.5278937,0.001255972,0.002533393,0.0002070265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984773,0.0001214607,0.0007120465,0.0002217948,0.0001352156,0.0002569603,0.00003732572,0.000006218555,0.00003171351],"genre_scores_gemma":[0.9977582,0.000277864,0.001540174,0.00003408505,0.00009209565,0.000007030229,0.0001648742,0.00001399658,0.0001117459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4419743,"threshold_uncertainty_score":0.3815491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015324909085189,"score_gpt":0.2320204318701219,"score_spread":0.21186718277927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}