{"id":"W1557320473","doi":"10.1007/978-3-642-27841-9_4501-2","title":"Pharmacokinetics and Pharmacodynamics in Drug Development","year":2015,"lang":"en","type":"book-chapter","venue":"","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Pharmacodynamics; Pharmacokinetics; Pharmacology; Drug; Drug development; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007940696,0.001352169,0.001209037,0.001162482,0.0002529713,0.001614709,0.0008729405,0.001186955,0.01522264],"category_scores_gemma":[0.001187986,0.0004450459,0.0004350566,0.001210929,0.0009867609,0.002004351,0.001061869,0.002755868,0.01287666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008131465,"about_ca_system_score_gemma":0.0009754902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007105079,"about_ca_topic_score_gemma":0.001347397,"domain_scores_codex":[0.9995554,0.0001129395,0.00001977511,0.00005016521,0.0002438222,0.00001791492],"domain_scores_gemma":[0.9996222,0.0002550366,0.00001959797,0.00002787528,0.00005936152,0.00001593963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004689462,0.00008752249,0.0001170404,0.000956174,0.00002685868,0.0001247978,0.0001281212,0.002657122,0.002593506,0.08056524,0.1379748,0.774722],"study_design_scores_gemma":[0.000009592518,0.00005687747,0.0002091161,0.0004562653,0.00001846345,0.0006148967,0.00002967547,0.001428467,0.001279476,0.07123199,0.9246479,0.00001732487],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001355921,0.6302375,0.1019462,0.006083431,0.005844539,0.00009518388,0.0004112584,0.000745665,0.2532803],"genre_scores_gemma":[0.01496276,0.4308316,0.0407273,0.005661966,0.004488875,0.0002323444,0.0004473549,0.0003910607,0.5022568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01522264,"threshold_uncertainty_score":0.05092478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1605324733345047,"score_gpt":0.4277001156353518,"score_spread":0.2671676423008471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}