{"id":"W1557481987","doi":"10.1038/ncomms8146","title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Memorial University of Newfoundland; Toronto Western Hospital; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Versus Arthritis; Medical Research Council; National Institutes of Health; National Institute for Health and Care Research; Arthritis Society; Agence Nationale de la Recherche; Wellcome Trust; National Health and Medical Research Council; European Commission; Arthritis Foundation","keywords":"Allele; Single-nucleotide polymorphism; Genetics; Haplotype; Ankylosing spondylitis; Human leukocyte antigen; Major histocompatibility complex; SNP; Biology; Genotype; HLA-B; Genetic association; Immunology; Epistasis; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032131,0.0001666833,0.0004553871,0.00009863608,0.0002996592,0.00001788971,0.0002066,0.0001407231,0.0000561264],"category_scores_gemma":[0.0002087911,0.0001414089,0.0000691316,0.000339682,0.0004241987,0.00006379187,0.000147989,0.0004028415,0.000003530616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508566,"about_ca_system_score_gemma":0.00009251588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587469,"about_ca_topic_score_gemma":0.008150463,"domain_scores_codex":[0.998881,0.0001427187,0.000306355,0.0002187137,0.000271876,0.0001793832],"domain_scores_gemma":[0.9974861,0.0002360551,0.0002585899,0.001199783,0.000667009,0.0001524345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001726535,0.0008800477,0.9874456,0.00004563007,0.0004195049,0.000008134748,0.00181369,0.000001311939,0.0001814362,0.002778924,0.004058232,0.002194815],"study_design_scores_gemma":[0.003051808,0.0002358065,0.9682986,0.000110734,0.0002201606,0.00003328596,0.001207308,0.00008960698,0.00003402949,0.0002993402,0.02628701,0.0001323215],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9404428,0.02152066,0.0000464431,0.02087256,0.00007765002,0.001636489,0.002724966,0.0001416143,0.0125368],"genre_scores_gemma":[0.9793698,0.0001346184,0.0186988,0.000424062,0.00002280946,0.0000558558,0.001222174,0.00002081683,0.00005108492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03892697,"threshold_uncertainty_score":0.5766488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1105520237955809,"score_gpt":0.352112813659351,"score_spread":0.2415607898637701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}