{"id":"W1557481987","doi":"10.1038/ncomms8146","title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Memorial University of Newfoundland; Toronto Western Hospital; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Versus Arthritis; Medical Research Council; National Institutes of Health; National Institute for Health and Care Research; Arthritis Society; Agence Nationale de la Recherche; Wellcome Trust; National Health and Medical Research Council; European Commission; Arthritis Foundation","keywords":"Allele; Single-nucleotide polymorphism; Genetics; Haplotype; Ankylosing spondylitis; Human leukocyte antigen; Major histocompatibility complex; SNP; Biology; Genotype; HLA-B; Genetic association; Immunology; Epistasis; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006700513,0.0003542612,0.0003632706,0.0005020768,0.0002478248,0.0003963794,0.0002393304,0.0002452862,0.00595349],"category_scores_gemma":[0.001639786,0.0001767332,0.0005392845,0.0007905813,0.0002247215,0.0001471443,0.0003812528,0.0003961969,0.0002828098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502857,"about_ca_system_score_gemma":0.0002136173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001558561,"about_ca_topic_score_gemma":0.002362682,"domain_scores_codex":[0.9990579,0.0004248047,0.00008130341,0.0001865382,0.0001533257,0.00009608642],"domain_scores_gemma":[0.9990006,0.000405814,0.000332338,0.00009410256,0.00006192916,0.0001052311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001563037,0.0001248699,0.8868377,0.0001475357,0.0025669,0.002049356,0.0003063348,0.0004882046,0.07066376,0.001072054,0.00134992,0.03283022],"study_design_scores_gemma":[0.00004153287,0.0001431795,0.9944273,0.000008649465,0.00029427,0.001804534,0.00006861223,0.0006065862,0.001273467,0.0003839114,0.0009406817,0.000007238161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966065,0.0006805322,0.001087834,0.0001652186,0.00001013656,0.000007465343,0.0002617847,0.00002391257,0.001156683],"genre_scores_gemma":[0.9983298,0.0001605681,0.0006739962,0.00004534805,0.00001252388,0.000006354395,0.0001725795,0.00001159835,0.0005873647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00595349,"threshold_uncertainty_score":0.01991642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1105520237955809,"score_gpt":0.352112813659351,"score_spread":0.2415607898637701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}