{"id":"W1558085653","doi":"10.18433/j34s4n","title":"Preclinical Pharmacokinetics of MI-219, a Novel Human Double Minute 2 (HDM2) Inhibitor and Prediction of Human Pharmacokinetics","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health","keywords":"Pharmacokinetics; Volume of distribution; Pharmacology; Distribution Volume; In vivo; NONMEM; Chemistry; Distribution (mathematics); Medicine; Biology; Mathematics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005012901,0.0003345897,0.0006284285,0.0004969191,0.0002687599,0.0001204932,0.001505133,0.00007550737,0.000135562],"category_scores_gemma":[0.0001489967,0.0002877985,0.0002987756,0.001108182,0.00115017,0.002031141,0.0006453368,0.0006589204,0.000002330875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006912703,"about_ca_system_score_gemma":0.0002626878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001713591,"about_ca_topic_score_gemma":5.95678e-7,"domain_scores_codex":[0.9948435,0.0004090093,0.001929385,0.0004313839,0.001724137,0.0006625433],"domain_scores_gemma":[0.9963231,0.0008950277,0.001277642,0.0002256859,0.0005671877,0.0007113275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002547379,0.001967649,0.03150958,0.0002270211,0.0001933377,0.000009193403,0.001016974,0.002325734,0.9290029,0.00725917,0.001289516,0.02494413],"study_design_scores_gemma":[0.009775951,0.0008580028,0.01347916,0.0001772473,0.0004765283,0.0003228017,0.00007550431,0.08330256,0.8653852,0.001142674,0.02456694,0.00043748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675251,0.00272371,0.02577214,0.0009838697,0.001836491,0.0003341965,0.00003476571,0.00003558927,0.0007541038],"genre_scores_gemma":[0.9694034,0.0003603879,0.02893288,0.0002915425,0.00096222,0.000005512056,0.000001791324,0.00001753006,0.00002470125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08097683,"threshold_uncertainty_score":0.9999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.203359012783645,"score_gpt":0.472163109251853,"score_spread":0.268804096468208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}